胰岛素和垂体肽β细胞促生素对泌乳和非泌乳大鼠棕色脂肪细胞中D-3-3H-葡萄糖掺入脂质的影响。
The effects of insulin and the pituitary peptide beta-cell tropin on the incorporation of D-3-3H-glucose into lipid in brown adipocytes from lactating and non-lactating rats.
作者信息
Davenport M, Morton J L, Beloff-Chain A, Dunmore S J, Cawthorne M A
机构信息
Clore Laboratory for the Biological Sciences, University of Buckingham, Bucks, U.K.
出版信息
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1437-41. doi: 10.1016/0006-291x(91)92100-x.
Lactating and non-lactating rat brown adipocytes were used to study the dose-dependent stimulation of lipogenesis by Beta-cell tropin (BCT) and insulin. In non-lactating animals BCT increased lipogenesis approximately 2-fold compared to a 3-fold stimulation with insulin; however BCT was effective at a substantially lower molar concentration than insulin. In lactating animals resistance was observed to both BCT and insulin action.
利用泌乳和非泌乳大鼠的棕色脂肪细胞研究β细胞促生素（BCT）和胰岛素对脂肪生成的剂量依赖性刺激作用。在非泌乳动物中，与胰岛素引起的3倍刺激相比，BCT使脂肪生成增加了约2倍；然而，BCT在远低于胰岛素的摩尔浓度下就有效。在泌乳动物中，观察到对BCT和胰岛素作用均有抵抗。
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