脂筏：仅从简单化的角度来看存在争议。
Lipid rafts: contentious only from simplistic standpoints.
作者信息
Hancock John F
机构信息
Institute for Molecular Bioscience, University of Queensland, Brisbane 4072, Australia.
出版信息
Nat Rev Mol Cell Biol. 2006 Jun;7(6):456-62. doi: 10.1038/nrm1925.
Abstract
The hypothesis that lipid rafts exist in plasma membranes and have crucial biological functions remains controversial. The lateral heterogeneity of proteins in the plasma membrane is undisputed, but the contribution of cholesterol-dependent lipid assemblies to this complex, non-random organization promotes vigorous debate. In the light of recent studies with model membranes, computational modelling and innovative cell biology, I propose an updated model of lipid rafts that readily accommodates diverse views on plasma-membrane micro-organization.
摘要
脂筏存在于质膜中并具有关键生物学功能这一假说仍存在争议。质膜中蛋白质的侧向异质性是无可争议的，但胆固醇依赖性脂质聚集体对这种复杂的、非随机组织的贡献引发了激烈的争论。鉴于最近对模型膜的研究、计算建模和创新细胞生物学，我提出了一个更新的脂筏模型，该模型很容易容纳关于质膜微观组织的各种观点。
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