Lin Fugui, Yan Li, Yuan Xiumei, Yang Xingwen, Yang Xiaoyan, Yang Yang, Ma Li, Wei Lianhua, Li Dehong
Department of Clinical Laboratory, Gansu Provincial Clinical Research Center for Laboratory Medicine, Lanzhou, China.
Department of Clinical Laboratory, Gansu Provincial Hospital, Lanzhou, China.
Biomark Med. 2025 Feb;19(3):91-99. doi: 10.1080/17520363.2025.2453411. Epub 2025 Jan 22.
Raftlin (raft-linking) protein is an essential component of the lipid raft structure and plays a crucial role in B and T cell signaling pathways. It facilitates B cell receptor (BCR) signaling by promoting calcium mobilization and tyrosine phosphorylation in the cells while colocalizing with BCR on the cell membrane. Interestingly, Raftlin is internalized in lipopolysaccharide-stimulated T cells by colocalization with Toll-like receptor 4 (TLR4), wherein it exerts a similar role as in B cells. The protein also effectuates poly(I:C) internalization into TLR3-positive endosomes in dendritic and epithelial cells through clathrin binding, thereby affecting interferon-β production. In addition, Raftlin controls the vascular endothelial cells and participates in cell growth and proliferation. Recent studies have indicated Raftlin to be a novel biomarker for the diagnosis due to its upregulated expression in malignant diseases. In this integrated study, we present the biological functions of Raftlin and its expression to provide a theoretical basis for the prevention, diagnosis, and treatment of various diseases.
筏联蛋白是脂筏结构的重要组成部分，在B细胞和T细胞信号通路中起关键作用。它通过促进细胞内钙动员和酪氨酸磷酸化，同时与细胞膜上的B细胞受体（BCR）共定位，来促进BCR信号传导。有趣的是，筏联蛋白在脂多糖刺激的T细胞中通过与Toll样受体4（TLR4）共定位而被内化，在其中发挥与在B细胞中类似的作用。该蛋白还通过网格蛋白结合，使多聚肌苷酸胞苷酸（poly(I:C)）内化到树突状细胞和上皮细胞的TLR3阳性内体中，从而影响干扰素-β的产生。此外，筏联蛋白调控血管内皮细胞，并参与细胞生长和增殖。最近的研究表明，由于筏联蛋白在恶性疾病中表达上调，它是一种新型的诊断生物标志物。在这项综合研究中，我们阐述了筏联蛋白的生物学功能及其表达情况，为各种疾病的预防、诊断和治疗提供理论依据。
