Leskinen-Kallio S, Någren K, Lehikoinen P, Ruotsalainen U, Joensuu H
Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.
Br J Cancer. 1991 Dec;64(6):1121-4. doi: 10.1038/bjc.1991.475.
L-[methyl-11-C]methionine (11C-methionine) uptake of seven primary breast cancers, four soft tissue metastases of breast cancer, and three other breast lesions was studied by positron emission tomography (PET). 11C-methionine accumulation was assessed by calculating the standardised uptake value (SUV). The mean SUV for breast cancer was 8.5 +/- 3.3 (s.d.), while the maximal uptake in the liver was 12.4 +/- 1.6, in the bone marrow 5.8 +/- 0.7, and in the myocardium 3.4 +/- 0.6. All eight malignant tumours larger than 30 mm in diameter accumulated clearly 11C-methionine, whereas none of the three smaller cancers (from 12 to 15 mm in diameter) were visualised. Strong uptake of 11C-methionine was associated with a large S-phase fraction (SPF) measured with flow cytometry (r = 0.77, P = 0.01), and the non-visualised cancers had all a small SPF (less than 5.5%). One benign tumour (an abscess) accumulated slightly 11C-methionine. The results indicate that both primary and metastatic breast cancer can be effectively imaged with 11C-methionine by PET, and that the accumulation of 11C-methionine may correlate with the proliferation rate of breast carcinoma.
采用正电子发射断层扫描（PET）研究了7例原发性乳腺癌、4例乳腺癌软组织转移灶及3例其他乳腺病变对L-[甲基-¹¹C]蛋氨酸（¹¹C-蛋氨酸）的摄取情况。通过计算标准化摄取值（SUV）评估¹¹C-蛋氨酸的蓄积情况。乳腺癌的平均SUV为8.5±3.3（标准差），而肝脏的最大摄取量为12.4±1.6，骨髓为5.8±0.7，心肌为3.4±0.6。所有8例直径大于30 mm的恶性肿瘤均明显蓄积¹¹C-蛋氨酸，而3例较小的癌症（直径12至15 mm）均未显影。¹¹C-蛋氨酸的强烈摄取与通过流式细胞术测得的大S期分数（SPF）相关（r = 0.77，P = 0.01），且未显影的癌症均具有小的SPF（小于5.5%）。1例良性肿瘤（脓肿）轻微蓄积¹¹C-蛋氨酸。结果表明，¹¹C-蛋氨酸PET可有效成像原发性和转移性乳腺癌，且¹¹C-蛋氨酸的蓄积可能与乳腺癌的增殖率相关。
