Syrota A, Duquesnoy N, Paraf A, Kellershohn C
Radiology. 1982 Apr;143(1):249-53. doi: 10.1148/radiology.143.1.6977792.
Positron emission tomography (PET) was used to assess possible pancreatic disease in 100 patients. Following injection of 10-15 mCi (370-740 MBq) of 11C-L-methionine, 4-12 transverse sections 2 cm thick were obtained. In 85 patients with a definite diagnosis (45 normal, 9 acute pancreatitis, 18 chronic pancreatitis, and 13 cancer), PET showed a sensitivity of 85.0%, a specificity of 97.8%, and an accuracy of 91.8%, higher than with transmission computed tomography (CT) or ultrasonography, despite relatively low spatial resolution; this can be explained by the fact that exocrine pancreatic function was altered prior to morphological change. In 22 normal subjects, 0.011 +/- 0.003% (mean +/- S.D). of injected 11C was found in 1 ml of liver tissue and 0.015 +/- 0.005% in 1 ml of pancreatic tissue; the pancreas-to-liver concentration ratio was 1.3 +/- 0.4. Hepatic 11C concentration was identical in the four groups of patients. Pancreatic uptake of 11C-L-methionine was significantly lower in patients with chronic pancreatitis (n = 13) and pancreatic carcinoma (n = 10) (p less than 0.001); however, it was not possible to distinguish cancer from chronic pancreatitis because the same functional alteration occurred in both.
正电子发射断层扫描（PET）用于评估100例患者可能存在的胰腺疾病。注射10 - 15毫居里（370 - 740兆贝可）的11C - L - 蛋氨酸后，获取了4 - 12个2厘米厚的横断面图像。在85例明确诊断的患者中（45例正常，9例急性胰腺炎，18例慢性胰腺炎，13例癌症），PET显示出85.0%的敏感性、97.8%的特异性和91.8%的准确性，尽管空间分辨率相对较低，但高于透射计算机断层扫描（CT）或超声检查；这可以通过外分泌胰腺功能在形态学改变之前就已改变这一事实来解释。在22名正常受试者中，每1毫升肝组织中发现注入的11C为0.011±0.003%（平均值±标准差），每1毫升胰腺组织中为0.015±0.005%；胰腺与肝脏的浓度比为1.3±0.4。四组患者的肝脏11C浓度相同。慢性胰腺炎患者（n = 13）和胰腺癌患者（n = 10）胰腺对11C - L - 蛋氨酸的摄取显著降低（p < 0.001）；然而，由于癌症和慢性胰腺炎都出现了相同的功能改变，因此无法区分两者。
