Sandner A, Börgermann J, Kösling S, Bloching M B
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Martin-Luther-Universität, Halle-Wittenberg.
HNO. 2006 Nov;54(11):861-7. doi: 10.1007/s00106-006-1396-5.
"Descending necrotizing mediastinitis" (DNM) is a rare but potentially life-threatening complication of deep neck infections caused by the rapid downward spread of a oropharyngeal infection along the facial planes into the mediastinum.
Between June 1997 and December 2004, 6 patients with DNM were treated in our department. The primary etiology was a peritonsillar abscess in 2 cases, a parapharyngeal abscess in 3 cases and in 1 case an odontogenic abscess. Most patients presented with risk factors such as diabetes mellitus or alcoholism, the mean age was 44.3 years and the mean duration of signs before diagnosis was 6.3 days. Thoracotomy was associated with the cervical approach in 4 cases and tracheostomy was also performed in 4 cases.
Four patients were successfully treated, the mean duration of hospitalisation was 48.2 days and 2 patients died from sepsis and multiorgan failure despite intensive treatment.
Descending necrotizing mediastinitis must be detected as soon as possible. The mean symptoms are persistent complaints after treatment of oropharyngeal infections, which may be masked by analgetic treatment. Only an immediate computer tomographic scanning, aggressive surgical drainage and debridement of the neck and the mediastinum can reduce the high mortality rate.
“下行性坏死性纵隔炎”(DNM)是一种罕见但可能危及生命的深部颈部感染并发症,由口咽感染沿面部平面迅速向下蔓延至纵隔引起。
1997年6月至2004年12月,我科共治疗6例DNM患者。主要病因中,2例为扁桃体周围脓肿,3例为咽旁脓肿,1例为牙源性脓肿。大多数患者存在糖尿病或酗酒等危险因素,平均年龄44.3岁,诊断前症状平均持续时间为6.3天。4例患者采用开胸手术联合颈部手术,4例患者还进行了气管切开术。
4例患者成功治愈,平均住院时间为48.2天,2例患者尽管接受了强化治疗,但仍死于败血症和多器官功能衰竭。
必须尽快检测出下行性坏死性纵隔炎。其平均症状是口咽感染治疗后持续存在的不适,可能被镇痛治疗掩盖。只有立即进行计算机断层扫描、积极的手术引流以及颈部和纵隔清创,才能降低高死亡率。