Atypical Extension to the Chest Wall of Descending Necrotizing Mediastinitis: A Rare Case in a 16-Year-Old Woman.

Descending necrotizing mediastinitis (DNM) is a severe and life-threatening infection requiring urgent diagnosis and aggressive management. We present the case of a 16-year-old woman with no prior medical history who developed DNM following an odontogenic infection, complicated by an unusual and rare extension to the chest wall. Such an atypical spread of infection is infrequent and poses additional diagnostic and therapeutic challenges. The use of anti-inflammatory drugs likely masked early symptoms, delaying recognition. Imaging confirmed extensive mediastinal involvement, necessitating prompt surgical intervention. The patient underwent aggressive surgical debridement via cervicothoracic approaches, followed by intensive postoperative care, leading to a favorable outcome. This case highlights the importance of early recognition and a multidisciplinary approach in DNM management, particularly when faced with atypical extensions beyond the mediastinum.