Pardo-Fernández J, Gutiérrez-Rivas E, Montero-Homs J, Navarro C
Servicio de Neurología, Hospital Clínico, Santiago de Compostela, A Coruña, Spain.
Rev Neurol. 2006;42(8):451-4.
Neuropathic pain (NPP) is defined as a pain started or caused by an injury to or dysfunction of the nervous system. Its treatment is different to that of nociceptive pain since it does not respond to conventional analgesics or non-steroidal antiinflammatory drugs.
To describe the treatment being received by patients with NPP in the daily clinical practice of the specialist in neurology.
An observational, epidemiological, cross-sectional study was conducted in 36 neurology units (24 extra-hospital and 12 belonging to hospitals). We collected the clinical data and the treatment administered to the first 20 patients with NPP to visit the neurology units over a period of 20 consecutive working days.
Data were collected for a total of 451 patients with NPP. The pharmacological groups most frequently used in patients with NPP attended in neurology units are antiepileptics (71%) and antidepressants (15%). Of these patients, 60% were being treated with a single drug (an antiepileptic agent in 84.5% of cases; antidepressants in 10.3%). Two pharmacological treatments were being received by 23.7%, and 2.3% of patients were given treatment involving three or more pharmacological agents. A total of 30% received non-pharmacological treatments, especially physiotherapy (50.4%).
Most patients with NPP attended in neurology units follow first-order pharmacological treatments (antiepileptics or antidepressants). Over half the patients are controlled with monotherapy, usually with an antiepileptic agent. Non-pharmacological treatments (especially physiotherapy) are used in a third of the patients.
神经性疼痛（NPP）被定义为由神经系统损伤或功能障碍引发或导致的疼痛。其治疗方法与伤害性疼痛不同，因为它对传统镇痛药或非甾体抗炎药无反应。
描述神经病学专家日常临床实践中NPP患者所接受的治疗。
在36个神经病学科室（24个院外科室和12个医院所属科室）进行了一项观察性、流行病学横断面研究。我们收集了连续20个工作日内首批前来神经病学科室就诊的20例NPP患者的临床资料及所接受的治疗。
共收集了451例NPP患者的数据。神经病学科室中NPP患者最常使用的药物类别是抗癫痫药（71%）和抗抑郁药（15%）。在这些患者中，60%接受单一药物治疗（84.5%的病例使用抗癫痫药；10.3%使用抗抑郁药）。23.7%的患者接受两种药物治疗，2.3%的患者接受三种或更多药物治疗。共有30%的患者接受非药物治疗，尤其是物理治疗（50.4%）。
在神经病学科室就诊的大多数NPP患者采用一级药物治疗（抗癫痫药或抗抑郁药）。超过半数的患者通过单一疗法得到控制，通常使用抗癫痫药。三分之一的患者使用非药物治疗（尤其是物理治疗）。
