McQuay H J
Nuffield Department of Anaesthetics, Oxford University, Abingdon.
Cancer Surv. 1988;7(1):141-59.
The current pharmacological management of neuropathic pain with antidepressants, anticonvulsants, drugs with action on the autonomic nervous system, steroids, baclofen and naloxone is reviewed. The underlying clinical theme of relative opioid insensitivity of neuropathic pain is emphasized. Future pharmacological approaches in neuropathic pain are suggested on the basis of the mechanism of action of the current remedies. The problems of clinical trials in this area are discussed.
本文综述了目前使用抗抑郁药、抗惊厥药、作用于自主神经系统的药物、类固醇、巴氯芬和纳洛酮治疗神经性疼痛的药理学方法。强调了神经性疼痛相对阿片类药物不敏感这一潜在临床主题。基于当前治疗方法的作用机制，提出了未来治疗神经性疼痛的药理学方法。并讨论了该领域临床试验的问题。
