degli Uberti E C, Bondanelli M, Ambrosio M R, Zatelli M C
Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Italy.
J Endocrinol Invest. 2005;28(11 Suppl International):70-2.
Diagnostic protocols for acromegaly have evolved over time reflecting the refinement of assays for the biochemical assessment of the GH-IGF-I axis and greater understanding of disease process. In February 1999, an International Consensus Conference was held in Cortina, Italy, to define the criteria for cure of acromegaly. This review paper summarizes the diagnostic guidelines proposed in the consensus statement by Giustina et al. In recent years, however, the criteria for both biochemical assessment and long-term monitoring in patients with acromegaly have changed with the development of increasingly sensitive and specific GH assays coupled with the widespread availability of reliable IGF-I assays. For this reason, constant updating of the assessment criteria proposed in the workshop held in Cortina, in 1999, would be advisable.
随着用于生长激素（GH）-胰岛素样生长因子-I（IGF-I）轴生化评估的检测方法不断完善以及对疾病过程的深入了解，肢端肥大症的诊断方案也历经演变。1999年2月，一场国际共识会议在意大利科尔蒂纳丹佩佐召开，旨在明确肢端肥大症的治愈标准。这篇综述文章总结了朱斯蒂娜等人在共识声明中提出的诊断指南。然而近年来，随着更敏感、特异的GH检测方法的发展以及可靠的IGF-I检测方法的广泛应用，肢端肥大症患者的生化评估和长期监测标准都发生了变化。因此，对1999年在科尔蒂纳丹佩佐举办的研讨会上提出的评估标准进行不断更新是明智之举。
