Sepúlveda B, Calle A, Lechuga L M, Armelles G
Instituto de Microelectrónica de Madrid (Centro Nacional de Microelectrónica-Consejo Superior de Investigaciones Cientificas), Isaac Newton 8, 28760 Tres Cantos, Madrid, Spain.
Opt Lett. 2006 Apr 15;31(8):1085-7. doi: 10.1364/ol.31.001085.
The characteristics of a novel magneto-optic surface-plasmon-resonance (MOSPR) sensor and its use for the detection of biomolecules are presented. This physical transduction principle is based on the combination of the magneto-optic activity of magnetic materials and a surface-plasmon resonance of metallic layers. Such a combination can produce a sharp enhancement of the magneto-optic effects that strongly depends on the optical properties of the surrounding medium, allowing its use for biosensing applications. Experimental characterizations of the MOSPR sensor have shown an increase in the limit of detection by a factor of 3 in changes of refractive index and in the adsorption of biomolecules compared with standard sensors. Optimization of the metallic layers and the experimental setup could result in an improvement of the limit of detection by as much as 1 order of magnitude.
介绍了一种新型磁光表面等离子体共振（MOSPR）传感器的特性及其在生物分子检测中的应用。这种物理传感原理基于磁性材料的磁光活性与金属层的表面等离子体共振相结合。这种结合可以使磁光效应急剧增强，而这种增强强烈依赖于周围介质的光学性质，从而使其可用于生物传感应用。与标准传感器相比，MOSPR传感器的实验表征表明，在折射率变化和生物分子吸附方面，检测限提高了3倍。金属层和实验装置的优化可使检测限提高多达1个数量级。
