Sieunarine Krishen, Hakim Nadey S, Corless David J, Noakes David E, Ungar Laszlo, Del Priore Giuseppe, Smith J Richard
Department of Gynaecology, Chelsea and Westminster Hospital at Imperial College School of Medicine, London, United Kingdom.
Int Surg. 2005 Nov-Dec;90(5):257-61.
Uterine auto-transplantation in the porcine model using a microvascular anastomotic technique failed because of gradual vessel thromboses. A macrovascular patch harvest with the uterus en bloc is probably less likely to undergo vessel thrombosis. The objective of this study was to assess the feasibility of an aortic/inferior vena caval vascular patch harvest with the uterus en bloc for uterine cross-transplantation purposes. A preserved human cadaver and freshly killed porcine and rabbit cadaveric models were used. The infrarenal aorta, inferior vena cava, common and internal iliac vessels and the uterine arterial and venous tree together with the uterus en bloc were successfully harvested intact as a large vessel patch and graft in both animal and human models. A macrovascular patch for uterine cross-transplantation is technically easy and feasible to harvest en bloc with the uterus in fresh cadaveric donors. This technique precludes live donors and makes cadaveric organ donation essential.
在猪模型中使用微血管吻合技术进行子宫自体移植因血管逐渐血栓形成而失败。整块摘取子宫并带有大血管补片可能不太容易发生血管血栓形成。本研究的目的是评估为子宫交叉移植目的整块摘取主动脉/下腔静脉血管补片并连带子宫的可行性。使用了保存的人类尸体以及新鲜处死的猪和兔尸体模型。在动物和人类模型中，均成功完整摘取了肾下主动脉、下腔静脉、髂总动脉和髂内动脉以及子宫动静脉树并连带子宫，作为一个大血管补片和移植物。在新鲜尸体供体中，为子宫交叉移植整块摘取带有子宫的大血管补片在技术上简单可行。该技术排除了活体供体，使尸体器官捐赠成为必需。
