Katritzky Alan R, Cai Chunming, Singh Sandeep K
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
J Org Chem. 2006 Apr 28;71(9):3375-80. doi: 10.1021/jo052443x.
Microwave reactions of primary and secondary amines with imidoylbenzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields. Convenient preparations of a variety of amides 5a-Ab (87-96%) and imidoylbenzotriazoles 6a-w (56-95%) have also been developed using microwave irradiation under mild conditions and short reaction times. These results demonstrate further the advantages of microwave synthesis and introduce a new application of imidoylbenzotriazoles in the preparation of polysubstituted amidines.
伯胺和仲胺与亚胺基苯并三唑6a - w的微波反应以76 - 94%的产率得到了多种取代的脒7a - Aa。在温和条件和短反应时间下使用微波辐射，还开发了各种酰胺5a - Ab（87 - 96%）和亚胺基苯并三唑6a - w（56 - 95%）的便捷制备方法。这些结果进一步证明了微波合成的优势，并引入了亚胺基苯并三唑在多取代脒制备中的新应用。
