Harmata Michael, Calkins Nathan L, Baughman Russell G, Barnes Charles L
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
J Org Chem. 2006 Apr 28;71(9):3650-2. doi: 10.1021/jo060175c.
The development of chiral ligands to direct the course and stereoselectivity of many catalytic asymmetric reactions is an important area of interest for many research groups. As part of a program examining the chemistry of 2,1-benzothiazines, we have prepared a new chiral benzothiazine ligand. This ligand can be made in as few as three steps from commercially available starting materials. Presented herein is the synthesis of the ligand along with the synthesis of a chiral molecular receptor that potentially presages a new class of chiral molecular tweezers.
开发用于指导许多催化不对称反应进程和立体选择性的手性配体，是许多研究团队感兴趣的一个重要领域。作为研究2,1-苯并噻嗪化学的项目的一部分，我们制备了一种新的手性苯并噻嗪配体。该配体可以从市售起始原料通过最少三步反应制备得到。本文介绍了该配体的合成以及一种手性分子受体的合成，该受体可能预示着一类新型手性分子镊子的出现。
