Ding Kuiling, Han Zhaobin, Wang Zheng
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
Chem Asian J. 2009 Jan 5;4(1):32-41. doi: 10.1002/asia.200800192.
This Focus Review highlights the exciting results obtained in the area of asymmetric catalysis using spirobiindane- or spirobifluorene-based chiral ligands. The spiro, mono, and bidentate ligands have been successfully applied in a wide range of transition-metal-catalyzed asymmetric reactions, including hydrogenations, carbon-carbon and carbon-heteroatom coupling reactions, with superior or comparable enantioselectivities to those obtained by using the related ligands bearing other backbones, thus proving that the spiro skeleton is a type of privileged structure for chiral ligand design. It is expected that the spiro concept for chiral ligand design will stimulate the future efforts to understand the features that account for their broad applicability and to apply this understanding to seek new privileged chiral ligands and catalysts.
本聚焦综述重点介绍了使用基于螺二氢茚或螺二芴的手性配体在不对称催化领域所取得的令人振奋的成果。螺、单齿和双齿配体已成功应用于广泛的过渡金属催化的不对称反应，包括氢化反应、碳 - 碳和碳 - 杂原子偶联反应，其对映选择性优于或可与使用具有其他骨架的相关配体所获得的对映选择性相媲美，从而证明螺骨架是手性配体设计中的一种优势结构类型。预计手性配体设计的螺概念将激发未来的研究工作，以了解使其具有广泛适用性的特征，并将这种认识应用于寻找新的优势手性配体和催化剂。
