Wasserman Danuta, Geijer Thomas, Sokolowski Marcus, Rozanov Vsevolod, Wasserman Jerzy
The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill-Health (NASP), Dep, of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
Behav Brain Funct. 2006 Apr 20;2:14. doi: 10.1186/1744-9081-2-14.
Serotonergic neurotransmission has been implicated in suicidal behavior. Association between suicidal completers and a regulatory C(-1019)G polymorphism (rs6295) in the serotonin 1A receptor (HTR1A) gene was previously reported, whereas a following study showed no association in a sample of suicide attempters.
The involvement of the implicated G-allele of the 5-HTR1A C(-1019)G polymorphism (rs6295) was analyzed with the transmission disequilibrium test (TDT) in a sample of 272 suicide attempter families.
No overtransmission of the G-allele was found in the entire sample of suicide attempters (p = 0.1460; n = 272 trios). However, a strong trend for overtransmission of the G-allele was observed in a sub-sample selected for a high level of previous traumatic and/or stressful life events prior to the suicide attempt (p = 0.0630, two-tail; n = 94 trios).
The current results show that variation at the rs6295 polymorphism of the HTR1A gene is not associated with suicide attempts generally. However, the results indicate a possible role of the G-allele in suicidal behavior in connection with high exposure to traumatic and/or stressful life events, which is in need of future investigation.
血清素能神经传递与自杀行为有关。先前有报道称自杀成功者与血清素1A受体（HTR1A）基因中的一个调控性C（-1019）G多态性（rs6295）之间存在关联，而随后的一项研究表明在自杀未遂者样本中不存在这种关联。
采用传递不平衡检验（TDT）对272个自杀未遂者家庭样本中的5 - HTR1A C（-1019）G多态性（rs6295）的G等位基因进行分析。
在整个自杀未遂者样本中未发现G等位基因的过度传递（p = 0.1460；n = 272个三联体）。然而，在一个为自杀未遂前有高水平既往创伤性和/或应激性生活事件而选取的子样本中，观察到G等位基因有强烈的过度传递趋势（p = 0.0630，双侧；n = 94个三联体）。
目前的结果表明，HTR1A基因rs6295多态性的变异一般与自杀未遂无关。然而，结果表明G等位基因在与高暴露于创伤性和/或应激性生活事件相关的自杀行为中可能起作用，这有待未来进一步研究。
