• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

I型干扰素的抗炎特性。

Anti-inflammatory properties of Type I interferons.

作者信息

Billiau Alfons

机构信息

Rega Institute, University of Leuven, Minderbroedersstraat 10, BE-3000 Leuven, Belgium.

出版信息

Antiviral Res. 2006 Sep;71(2-3):108-16. doi: 10.1016/j.antiviral.2006.03.006. Epub 2006 Apr 4.

DOI:10.1016/j.antiviral.2006.03.006
PMID:16626815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7114336/
Abstract

The notion that Type I interferons (interferon-alpha and -beta) possess anti-inflammatory potential is supported by data from clinical application in multiple sclerosis, by studies on cultured immune-competent cells and by investigation of experimental diseases in whole animals. These observations deserve the attention of virologists for their potential role in the pathogenesis and clinical management of virus infections.

摘要

I型干扰素（α干扰素和β干扰素）具有抗炎潜力这一观点，得到了来自多发性硬化症临床应用数据、对培养的免疫活性细胞的研究以及对整体动物实验性疾病的调查的支持。这些观察结果因其在病毒感染的发病机制和临床管理中的潜在作用，值得病毒学家关注。

相似文献

1
Anti-inflammatory properties of Type I interferons.I型干扰素的抗炎特性。
Antiviral Res. 2006 Sep;71(2-3):108-16. doi: 10.1016/j.antiviral.2006.03.006. Epub 2006 Apr 4.
2
Overview of the biology of type I interferons.I 型干扰素的生物学概述。
Arthritis Res Ther. 2010;12 Suppl 1(Suppl 1):S1. doi: 10.1186/ar2881. Epub 2010 Apr 14.
3
Interferons: the pathways of discovery. II. Immunomodulatory, in vivo and applied aspects.干扰素：发现之路。II. 免疫调节、体内及应用方面。
J Clin Virol. 2007 Aug;39(4):241-65. doi: 10.1016/j.jcv.2007.04.023. Epub 2007 Jun 18.
4
Implications for clinical application of new developments in interferon research.
Biochim Biophys Acta. 1982 Sep 30;695(1):49-67. doi: 10.1016/0304-419x(82)90006-3.
5
[The first answer to viral infections: type I interferon].[病毒感染的首个应答：I型干扰素]
Berl Munch Tierarztl Wochenschr. 2004 Jul-Aug;117(7-8):252-65.
6
IFN-α subtypes: distinct biological activities in anti-viral therapy.IFN-α 亚型：抗病毒治疗中的不同生物学活性。
Br J Pharmacol. 2013 Mar;168(5):1048-58. doi: 10.1111/bph.12010.
7
Glucocorticoid and type 1 interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis.
Neuroreport. 2001 Jul 20;12(10):2189-93. doi: 10.1097/00001756-200107200-00029.
8
Type I interferons as anti-inflammatory mediators.I型干扰素作为抗炎介质。
Sci STKE. 2007 Dec 11;2007(416):pe70. doi: 10.1126/stke.4162007pe70.
9
Antiviral therapy.
Adv Exp Med Biol. 1987;209:297-304. doi: 10.1007/978-1-4684-5302-7_43.
10
Type I Interferon in Chronic Virus Infection and Cancer.Ⅰ型干扰素在慢性病毒感染和癌症中的作用
Trends Immunol. 2017 Aug;38(8):542-557. doi: 10.1016/j.it.2017.05.005. Epub 2017 May 31.

引用本文的文献

1
Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma.用于治疗病毒感染以预防哮喘气道重塑的药物。
Mediators Inflamm. 2025 Jul 24;2025:5526526. doi: 10.1155/mi/5526526. eCollection 2025.
2
Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics.多组学揭示恒河猴中SIV对脑髓样细胞群体的转化
Commun Biol. 2025 Jan 21;8(1):100. doi: 10.1038/s42003-024-07443-4.
3
Transformation of brain myeloid cell populations by SIV in rhesus macaques revealed by multiomics.多组学揭示恒河猴中SIV对脑髓样细胞群体的转化
Res Sq. 2024 Sep 18:rs.3.rs-4916594. doi: 10.21203/rs.3.rs-4916594/v1.
4
PepNet: an interpretable neural network for anti-inflammatory and antimicrobial peptides prediction using a pre-trained protein language model.PepNet：一种基于预训练蛋白质语言模型的可解释神经网络，用于预测抗炎和抗菌肽。
Commun Biol. 2024 Sep 28;7(1):1198. doi: 10.1038/s42003-024-06911-1.
5
Anti-inflammatory roles of type I interferon signaling in the lung.I 型干扰素信号在肺部的抗炎作用。
Am J Physiol Lung Cell Mol Physiol. 2024 May 1;326(5):L551-L561. doi: 10.1152/ajplung.00353.2023. Epub 2024 Feb 20.
6
Emerging Roles of Type-I Interferons in Neuroinflammation, Neurological Diseases, and Long-Haul COVID.I 型干扰素在神经炎症、神经疾病和长新冠中的新兴作用。
Int J Mol Sci. 2022 Nov 19;23(22):14394. doi: 10.3390/ijms232214394.
7
Recombinant Interferon-β in the Treatment of Polycythemia Vera and Related Neoplasms: Rationales and Perspectives.重组干扰素-β在真性红细胞增多症及相关肿瘤治疗中的应用：理论依据与前景
Cancers (Basel). 2022 Nov 9;14(22):5495. doi: 10.3390/cancers14225495.
8
Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions.干扰素在疼痛和感染中的作用：神经免疫和神经胶质相互作用中的新角色。
Front Immunol. 2021 Nov 5;12:783725. doi: 10.3389/fimmu.2021.783725. eCollection 2021.
9
Benefits of Cardamom ( (L.) Maton) and Turmeric ( L.) Extracts for Their Applications as Natural Anti-Inflammatory Adjuvants.小豆蔻（(L.) Maton）和姜黄（L.）提取物作为天然抗炎佐剂应用的益处。
Plants (Basel). 2021 Sep 14;10(9):1908. doi: 10.3390/plants10091908.
10
A Hepatitis B Virus-Derived Peptide Can Inhibit Infection of Human Lung Cells with SARS-CoV-2 in a Type-1 Interferon-Dependent Manner.一种乙型肝炎病毒衍生肽可通过 I 型干扰素依赖的方式抑制 SARS-CoV-2 感染人肺细胞。
Viruses. 2021 Jun 25;13(7):1227. doi: 10.3390/v13071227.

本文引用的文献

1
Prevention of hepatocellular carcinoma and its recurrence in chronic hepatitis C patients by interferon therapy.
Clin Gastroenterol Hepatol. 2005 Oct;3(10 Suppl 2):S141-3. doi: 10.1016/s1542-3565(05)00713-5.
2
Using pegylated interferon and ribavirin to treat patients with chronic hepatitis C.
Am Fam Physician. 2005 Aug 15;72(4):655-62.
3
Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment.多发性硬化症患者血清基质金属蛋白酶-9/金属蛋白酶组织抑制因子-1及基质金属蛋白酶-2/金属蛋白酶组织抑制因子-2比值：与干扰素β-1a治疗期间疾病活动度不同磁共振成像测量指标的关系
Mult Scler. 2005 Aug;11(4):441-6. doi: 10.1191/1352458505ms1193oa.
4
Effect of interferon on incidence of hepatocellular carcinoma in patients with chronic hepatitis C.干扰素对慢性丙型肝炎患者肝细胞癌发生率的影响。
Hepatogastroenterology. 2005 Jul-Aug;52(64):1154-8.
5
Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B.聚乙二醇干扰素α-2a、拉米夫定及两者联合治疗HBeAg阳性慢性乙型肝炎
N Engl J Med. 2005 Jun 30;352(26):2682-95. doi: 10.1056/NEJMoa043470.
6
Suppression of haematopoiesis during therapy of chronic hepatitis C with different interferon alpha mono and combination therapy regimens.不同干扰素α单药及联合治疗方案治疗慢性丙型肝炎期间造血功能的抑制
Gut. 2005 Jul;54(7):1014-20. doi: 10.1136/gut.2004.057893.
7
IL-6 produced by type I IFN DC controls IFN-gamma production by regulating the suppressive effect of CD4+ CD25+ regulatory T cells.I型干扰素依赖性树突状细胞产生的白细胞介素-6通过调节CD4+CD25+调节性T细胞的抑制作用来控制γ干扰素的产生。
Hum Immunol. 2005 May;66(5):460-8. doi: 10.1016/j.humimm.2005.01.012. Epub 2005 Feb 26.
8
Intrahepatic CD8+ T-lymphocyte response is important for therapy-induced viral clearance in chronic hepatitis B infection.肝内CD8 + T淋巴细胞反应对于慢性乙型肝炎感染中治疗诱导的病毒清除至关重要。
J Hepatol. 2005 Jul;43(1):45-52. doi: 10.1016/j.jhep.2005.01.038. Epub 2005 Apr 25.
9
Chemokine up-regulation in SARS-coronavirus-infected, monocyte-derived human dendritic cells.严重急性呼吸综合征冠状病毒感染的人单核细胞来源树突状细胞中趋化因子的上调
Blood. 2005 Oct 1;106(7):2366-74. doi: 10.1182/blood-2004-10-4166. Epub 2005 Apr 28.
10
Antiviral treatment with alpha interferon up-regulates CD14 on liver macrophages and its soluble form in patients with chronic hepatitis B.慢性乙型肝炎患者接受α干扰素抗病毒治疗可上调肝巨噬细胞及其可溶性形式的CD14。
Antimicrob Agents Chemother. 2005 Feb;49(2):590-9. doi: 10.1128/AAC.49.2.590-599.2005.