双侧输卵管卵巢切除术（BSO）后的恶性肿瘤。

Malignancies following bilateral salpingo-oophorectomy (BSO).

作者信息

Gotlieb W H, Barchana M, Ben-Baruch G, Friedman E

机构信息

Division of Gynecologic Oncology, Jewish General Hospital - McGill University, Montreal, Canada.

出版信息

Eur J Surg Oncol. 2006 Dec;32(10):1231-4. doi: 10.1016/j.ejso.2006.03.021. Epub 2006 Apr 19.

DOI:10.1016/j.ejso.2006.03.021

PMID:16626923

Abstract

AIMS

Prophylactic bilateral salpingo-oophorectomy (BSO) is an effective risk reducing measure in ovarian cancer susceptible women. Yet, a small subset of women develop primary peritoneal carcinomatosis (PPC) after BSO. The rates of PPC following non-risk reducing BSO have sparingly been reported.

METHODS

Women who underwent BSO for non-cancer reasons from 1/1/1984 to 12/31/2000 were crossed with the list of cancer diagnoses reported to the Israel National Cancer Registry until 12/31/2001.

RESULTS

Overall, 4128 women at a mean age of 58+/-12 years were analyzed. After a mean of 7.2+/-4 years following BSO, 147 women (3.6%) were diagnosed with cancer: breast cancer in 50 women 62+/-50 months after BSO, and one patient developed PPC, whereas the expected was 0.15 cases. The Standardized Incidence Ratio (SIR) of developing breast cancer was statistically significant lower than expected (SIR 0.71, 95% C.I. 0.44-0.78).

CONCLUSION

The rate of post-oophorectomy PPC in average risk population is low, and BSO appears to lower the rate of breast cancer in average risk women.

摘要

目的

预防性双侧输卵管卵巢切除术（BSO）是降低卵巢癌易感女性发病风险的有效措施。然而，一小部分女性在接受BSO后发生原发性腹膜癌（PPC）。关于非降低风险目的的BSO术后PPC发生率的报道较少。

方法

将1984年1月1日至2000年12月31日因非癌症原因接受BSO的女性名单与截至2001年12月31日向以色列国家癌症登记处报告的癌症诊断名单进行比对。

结果

共分析了4128名平均年龄为58±12岁的女性。在BSO术后平均7.2±4年，147名女性（3.6%）被诊断患有癌症：50名女性在BSO术后62±50个月患乳腺癌，1例患者发生PPC，而预期应为0.15例。患乳腺癌的标准化发病比（SIR）显著低于预期（SIR 0.71，95%置信区间0.44 - 0.78）。