Tupala Erkki, Halonen Pirjo, Tiihonen Jari
Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, Kuopio, Finland.
Eur Neuropsychopharmacol. 2006 Dec;16(8):552-60. doi: 10.1016/j.euroneuro.2006.02.008. Epub 2006 Apr 19.
We measured cortical dopamine transporter (DAT) in Cloninger type 1 and 2 alcoholics by using [(125)I]PE2I as a radioligand in human postmortem whole hemispheric autoradiography, and evaluated the putative correlations of DAT between cortical areas and nucleus accumbens. There was a low, but distinct cortical binding in the cryosections. The mean binding was generally higher in both groups of alcoholics compared to controls, and the results reached statistical significance with a large effect size (1.25) in the temporal cortex of type 2 alcoholics. This is surprising, because several studies have reported lower DAT densities in the striatum among alcoholics compared to controls. Moreover, the density of DAT had a statistically significant positive correlation between temporal cortex and nucleus accumbens in controls, whereas among type 2 alcoholics the correlation was statistically significantly negative, which may suggest some pathology relating to the antisocial behaviour of these alcoholics.
我们通过在人类死后全脑半球放射自显影中使用[(125)I]PE2I作为放射性配体，测量了克隆宁格1型和2型酗酒者的皮质多巴胺转运体（DAT），并评估了皮质区域与伏隔核之间DAT的假定相关性。在冷冻切片中有较低但明显的皮质结合。与对照组相比，两组酗酒者的平均结合通常更高，并且在2型酗酒者的颞叶皮质中，结果达到了具有大效应量（1.25）的统计学显著性。这令人惊讶，因为几项研究报告称，与对照组相比，酗酒者纹状体中的DAT密度较低。此外，对照组中颞叶皮质与伏隔核之间DAT的密度具有统计学显著的正相关，而在2型酗酒者中，这种相关性在统计学上是显著负相关，这可能表明这些酗酒者的反社会行为存在某种病理情况。
