Masutani S, Sasaki Y, Imaoka S, Ohashi I, Ishikawa O, Furukawa H, Fukuda I, Kabuto T, Fujita M, Koyama H
Department of Surgery, Center for Adult diseases, Osaka.
Nihon Shokakibyo Gakkai Zasshi. 1991 Nov;88(11):2757-62.
In 180 patients with hepatocellular carcinoma (HCC) who underwent radical hepatectomy, 52 patients were received preoperative arterial chemoembolization (TAE) for the whole liver (whole-liver TAE group: group A), 39 for the limited area of the liver (lobar or segmental TAE group: group B) and the remaining 89 had no treatments before surgery (control group: group C). In order to evaluate the significance of preoperative TAE, long-term prognoses were compared among the three groups. Although there were no significant differences in survivals between A and C, the 2- and 6-year survivals in group B were significantly better than those in group C (P less than 0.05). With regard to reduction rates of tumors and necrotizing effect for daughter nodules after TAE, the lobar or segmental TAE was significantly superior to the whole-liver TAE. Moreover, the lobar or segmental TAE deteriorated the liver function significantly less than the whole-liver TAE. These findings suggest that the lobar or segmental TAE is more advantageous than the whole-liver TAE as a preoperative adjuvant therapy.
在180例行根治性肝切除术的肝细胞癌（HCC）患者中，52例接受了全肝术前动脉化疗栓塞（TAE）（全肝TAE组：A组），39例接受了肝局部区域（叶或段TAE）的TAE（叶或段TAE组：B组），其余89例术前未接受治疗（对照组：C组）。为了评估术前TAE的意义，比较了三组的长期预后。虽然A组和C组的生存率无显著差异，但B组的2年和6年生存率显著优于C组（P<0.05）。关于TAE后肿瘤缩小率和子结节坏死效果，叶或段TAE明显优于全肝TAE。此外，叶或段TAE对肝功能的损害明显小于全肝TAE。这些发现表明，叶或段TAE作为术前辅助治疗比全肝TAE更具优势。
