长期增强效应的诱导与即刻早期基因的激活之间存在负相关。

A negative correlation between the induction of long-term potentiation and activation of immediate early genes.

作者信息

Schreiber S S, Maren S, Tocco G, Shors T J, Thompson R F

机构信息

Department of Neurology, University of Southern California School of Medicine, Los Angeles 90033.

出版信息

Brain Res Mol Brain Res. 1991 Aug;11(1):89-91. doi: 10.1016/0169-328x(91)90025-s.

DOI:10.1016/0169-328x(91)90025-s

PMID:1662748

Abstract

In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos and zif/268) using several different high-frequency stimulation paradigms. Stimulation parameters that effectively induced LTP were not associated with IEG activation. Conversely, stimulation parameters that failed to induce LTP consistently resulted in IEG activation. These results suggest that there is a negative correlation between IEG activation and LTP, and that activation of IEGs is neither necessary nor sufficient for the induction of LTP.

摘要

在本研究中，我们使用几种不同的高频刺激模式，研究了麻醉大鼠齿状回中长时程增强（LTP）的诱导与即刻早期基因（IEGs；c-fos和zif/268）激活之间的关系。有效诱导LTP的刺激参数与IEG激活无关。相反，未能诱导LTP的刺激参数始终导致IEG激活。这些结果表明，IEG激活与LTP之间存在负相关，并且IEG的激活对于LTP的诱导既不是必需的也不是充分的。