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ArgBP2, encoding a negative regulator of ABL, is fused to MLL in a case of infant M5 acute myeloid leukemia involving 4q35 and 11q23.

作者信息

Pession A, Lo Nigro L, Montemurro L, Serravalle S, Fazzina R, Izzi G, Nucifora G, Slany R, Tonelli R

出版信息

Leukemia. 2006 Jul;20(7):1310-3. doi: 10.1038/sj.leu.2404222. Epub 2006 Apr 20.

DOI:10.1038/sj.leu.2404222
PMID:16628191
Abstract
摘要

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ArgBP2, encoding a negative regulator of ABL, is fused to MLL in a case of infant M5 acute myeloid leukemia involving 4q35 and 11q23.
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Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia.对一名婴儿急性单核细胞白血病中由涉及MLL的t(6;11)(q27;q23)染色体易位导致的重排基因组和嵌合mRNA进行分子分析。
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[Mutational detection of full-length mixed lineage leukemia gene in patients with de novo AML-M4 and M5].[初发急性髓系白血病M4和M5患者全长混合谱系白血病基因的突变检测]
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Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23).在携带t(9;11)(p22;q23)的急性髓系白血病M5细胞系中,MLL-AF9、MLL和MYC表达的下调对于单核细胞-巨噬细胞成熟并非必需。
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