Roignot Julie, Soubeyran Philippe
INSERM U, Parc Scientifique et Technologique de Luminy, Marseille, France.
Cell Adh Migr. 2009 Apr-Jun;3(2):167-70. doi: 10.4161/cam.3.2.7576. Epub 2009 Apr 5.
ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of actin-dependent processes such as cell adhesion and migration. Recent data from our lab revealed that by regulating adhesion and migration of pancreatic cancer cells, ArgBP2 is endowed with an anti-tumoral function. We could show that part of the molecular mechanism involved the interaction of ArgBP2 with the Arp2/3 activator WAVE1, the tyrosine phosphatase PTP-PEST, and the tyrosine kinase c-Abl. As ArgBP2 shares common structural organization and overlapping functions with the two other members of this protein family, CAP and Vinexin, it raises the question whether these two other proteins could also be involved in cancer diseases. The control of cell migration being an important issue in tumor treatment, these recent findings suggest that ArgBP2 family-dependent signaling pathways represents potential targets for the development of therapeutic strategies, and highlight the importance of elucidating their molecular mechanisms of cytoskeletal regulation.
接头蛋白SoHo家族成员ArgBP2是肌动蛋白依赖性过程（如细胞黏附和迁移）的调节因子。我们实验室最近的数据显示，通过调节胰腺癌细胞的黏附和迁移，ArgBP2具有抗肿瘤功能。我们能够证明，部分分子机制涉及ArgBP2与Arp2/3激活剂WAVE1、酪氨酸磷酸酶PTP-PEST以及酪氨酸激酶c-Abl的相互作用。由于ArgBP2与该蛋白家族的另外两个成员CAP和Vinexin具有共同的结构组织和重叠功能，这就提出了一个问题，即这另外两种蛋白是否也参与癌症疾病。细胞迁移的控制是肿瘤治疗中的一个重要问题，这些最新发现表明，ArgBP2家族依赖性信号通路是治疗策略开发的潜在靶点，并突出了阐明其细胞骨架调节分子机制的重要性。
