Collis Michael C
British Pharmacological Society, London, UK.
Nat Rev Drug Discov. 2006 May;5(5):377-9. doi: 10.1038/nrd2036.
In vivo animal experiments are essential (and a regulatory requirement) to demonstrate the potential efficacy, safety and pharmacodynamic/pharmacokinetic profile of candidate drugs. However, the number of pharmacologists (and other bioscientists) with integrative (in vivo) pharmacology skills has been in decline for a number of years, as have the opportunities for students to learn such skills. This article reviews some recent initiatives that are underway to rebuild this essential skills base in the United Kingdom and the United States. Partnerships between industry and national funders of research and education have proved to be a particularly effective approach to support this strategically important area of biological science.
体内动物实验对于证明候选药物的潜在疗效、安全性以及药效学/药代动力学特征至关重要（也是一项监管要求）。然而，具备综合（体内）药理学技能的药理学家（以及其他生物科学家）数量多年来一直在减少，学生学习此类技能的机会也同样如此。本文回顾了英国和美国近期为重建这一关键技能基础而开展的一些举措。事实证明，行业与研究及教育的国家资助者之间的合作关系是支持这一具有战略重要性的生物科学领域的一种特别有效的方式。
