Alcântara-Jones Daysi M de, Araújo Leila Maria Batista, Almeida Alessandro de M, Jones Daniel de Alcântara, Cardoso Lázaro José Góes, Passos Marize Carvalho
Universidade Federal da Bahia, RJ.
Arq Bras Endocrinol Metabol. 2006 Feb;50(1):97-104. doi: 10.1590/s0004-27302006000100014. Epub 2006 Apr 17.
To verify the effectiveness of percutaneous ethanol injection (PEI) in the treatment of thyroid nodules (TN), we analyzed 86 TN from 77 patients before and after one or two sessions of PEI. The medians of the initial and final volumes were: 3.5 mL (range 0.3-82.7) and 1.8 mL (range 0-29.4). Seven percent of the nodules disappeared and the mean nodule size reduction was 52.6% (p< 0.0001). After ethanol injection, the median volume reduction was: 37.3% (range -39.0-82.6) for solid; 53.5% (14.6-88.0) for mostly solid; 58.0% (21.0-64.5) for mixed; 71.0% (18.8-100.0) for mostly cystic and 90.0% (45.9-100.0) for cystic lesions. Furthermore, we compared the variation of the greatest diameter of TN, without any treatment and after PEI, and found this difference statistically significant (p< 0.00001). Pain was the most common complication, although this was mostly described as moderate (27.6%). We conclude that PEI is an efficient and safe treatment option for benign TN.
为验证经皮乙醇注射（PEI）治疗甲状腺结节（TN）的有效性，我们分析了77例患者的86个甲状腺结节在一或两次PEI治疗前后的情况。初始体积和最终体积的中位数分别为：3.5毫升（范围0.3 - 82.7）和1.8毫升（范围0 - 29.4）。7%的结节消失，结节平均大小缩小52.6%（p < 0.0001）。乙醇注射后，实性结节体积减少中位数为：37.3%（范围 - 39.0 - 82.6）；大部分实性结节为53.5%（14.6 - 88.0）；混合性结节为58.0%（21.0 - 64.5）；大部分囊性结节为71.0%（18.8 - 100.0）；囊性病变为90.0%（45.9 - 100.0）。此外，我们比较了未经治疗和PEI治疗后甲状腺结节最大直径的变化，发现这种差异具有统计学意义（p < 0.00001）。疼痛是最常见的并发症，不过大多描述为中度（27.6%）。我们得出结论，PEI是治疗良性甲状腺结节的一种有效且安全的选择。
