Trasande Leonardo, Cronk Christine E, Leuthner Steven R, Hewitt Jeanne B, Durkin Maureen S, McElroy Jane A, Anderson Henry A, Landrigan Philip J
Center for Children's Health and the Environment, Mount Sinai School of Medicine, New York, NY 10029, USA.
WMJ. 2006 Mar;105(2):50-4.
Prospective, multi-year epidemiologic studies such as the Framingham Heart Study and the Nurses' Health Study have proven highly effective in identifying risk factors for chronic illness and in guiding disease prevention. Now, in order to identify environmental risk factors for chronic disease in children, the US Congress authorized a National Children's Study as part of the Children's Health Act of 2000. Enrollment of a nationally representative cohort of 100,000 children will begin in 2008, with follow-up to continue through age 21. Environmental assessment and examination of biomarkers collected at specified intervals during pregnancy and childhood will be a major component of the Study. Recruitment at 105 sites across the United States is planned, and will begin at 7 Vanguard Centers in 2008, including Waukesha County, Wis. The National Children's Study will provide information on preventable risk factors for such chronic diseases as asthma, certain birth defects, neurobehavioral syndromes, and obesity. In addition, the National Children's Study will provide training in pediatric environmental health for the next generation of researchers and practitioners.
前瞻性的多年流行病学研究，如弗雷明汉心脏研究和护士健康研究，已被证明在识别慢性病风险因素和指导疾病预防方面非常有效。现在，为了识别儿童慢性病的环境风险因素，美国国会批准了一项全国儿童研究，作为2000年《儿童健康法案》的一部分。一个具有全国代表性的10万名儿童队列将于2008年开始招募，并将持续跟踪至21岁。在孕期和儿童期的特定时间间隔收集生物标志物进行环境评估和检测将是该研究的一个主要组成部分。计划在美国105个地点进行招募，并将于2008年在7个先锋中心开始，包括威斯康星州的沃基夏县。全国儿童研究将提供有关哮喘、某些出生缺陷、神经行为综合征和肥胖等慢性病可预防风险因素的信息。此外，全国儿童研究将为下一代研究人员和从业者提供儿科环境卫生方面的培训。
