Trasande Leonardo, Cronk Chris, Durkin Maureen, Weiss Marianne, Schoeller Dale, Gall Elizabeth, Hewitt Jeanne, Carrel Aaron, Landrigan Philip, Gillman Matthew
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Cien Saude Colet. 2010 Jan;15(1):195-210. doi: 10.1590/s1413-81232010000100025.
We describe the approach taken by the National Children's Study (NCS) to understanding the role of environmental factors in the development of obesity. We review the literature with regard to the two core hypotheses in the NCS that relate to environmental origins of obesity and describe strategies that will be used to test each hypothesis. Although it is clear that obesity in an individual results from an imbalance between energy intake and expenditure, control of the obesity epidemic will require understanding of factors in the modern built environment and chemical exposures that may have the capacity to disrupt the link between energy intake and expenditure. Through its embrace of the life-course approach to epidemiology, the NCS will be able to study the origins of obesity from preconception through late adolescence, including factors ranging from genetic inheritance to individual behaviors to the social, built, and natural environment and chemical exposures. It will have sufficient statistical power to examine interactions among these multiple influences, including gene-environment and gene-obesity interactions. A major secondary benefit will derive from the banking of specimens for future analysis.
我们描述了国家儿童研究（NCS）为理解环境因素在肥胖症发展中所起作用而采取的方法。我们回顾了与NCS中两个与肥胖症环境起源相关的核心假设有关的文献，并描述了将用于检验每个假设的策略。虽然很明显个体肥胖是由能量摄入与消耗之间的不平衡导致的，但要控制肥胖症流行，就需要了解现代建筑环境和化学暴露中可能有能力破坏能量摄入与消耗之间联系的因素。通过采用生命历程流行病学方法，NCS将能够研究从孕前到青春期后期肥胖症的起源，包括从遗传继承到个体行为，再到社会、建筑和自然环境以及化学暴露等各种因素。它将拥有足够的统计能力来检验这些多种影响之间的相互作用，包括基因 - 环境和基因 - 肥胖症相互作用。一个主要的附带益处将来自于为未来分析而储存样本。
