Coco C, Magistrelli P, Vecchio F M, Roncolini G, Granone P, D'Ugo D, Picciocchi A
Istituto di Semeiotica Chirurgica, Università Cattolica del Sacro Cuore, Roma.
Ann Ital Chir. 1991 Jul-Aug;62(4):355-62.
An univariate analysis of pathologic data of 987 patients with primary colorectal carcinoma treated over a period of 22 years was performed. Six variables such as tumor site, histologic type, depth of invasion, nodal involvement, distant metastases, histologic grade and tumor stage were tested for their prognostic value. 5-year survival rate was investigated. Patients with tumors in the left colon and rectum have shown a better prognosis than patients with tumors in the right colon (53-51% vs. 38% p = 0.0007). As regard histologic type non significant differences between mucinous and non-mucinous carcinoma was observed (44% vs 48% respectively p = 0.4). The depth of tumor invasion was an important prognostic factor; according to tumor infiltration patients can be divided in four groups (T1, T2, T3, T4) with 5-year survival rates of 80%, 74%, 39% and 16% respectively (p = 0.0000). Highly significant decrements in survival occurred when lymph node metastases were demonstrable (20% vs. 67% p = 0.0000). Prognosis was still strongly related to histologic grade, with significant difference in survival rates between G1 and G2-G3 tumors (71% vs. 48%-42% p = 0.0000). Finally prognosis was closely related to the stage of spread at the time of diagnosis.
对987例在22年期间接受治疗的原发性结直肠癌患者的病理数据进行了单因素分析。对肿瘤部位、组织学类型、浸润深度、淋巴结受累情况、远处转移、组织学分级和肿瘤分期等六个变量的预后价值进行了检测。研究了5年生存率。左半结肠和直肠肿瘤患者的预后优于右半结肠肿瘤患者（53%-51%对38%，p = 0.0007）。关于组织学类型，黏液性癌和非黏液性癌之间未观察到显著差异（分别为44%对48%，p = 0.4）。肿瘤浸润深度是一个重要的预后因素；根据肿瘤浸润情况，患者可分为四组（T1、T2、T3、T4），5年生存率分别为80%、74%、39%和16%（p = 0.0000）。当出现淋巴结转移时，生存率显著下降（20%对67%，p = 0.0000）。预后仍与组织学分级密切相关，G1肿瘤与G2-G3肿瘤的生存率有显著差异（71%对48%-42%，p = 0.0000）。最后，预后与诊断时的扩散阶段密切相关。
