Kamsa-ard Supot, Wiangnon Surapon, Kamsa-ard Siriporn, Suwanrungruang Krittika, Jetsrisuparb Arunee, Horsith Sujinant
Faculty of Public Health, Khon Kaen University, Khon Kaen, 40002, Thailand.
Asian Pac J Cancer Prev. 2006 Jan-Mar;7(1):75-8.
The Khon Kaen Cancer Registry (KKCR), providing both hospital and population-based registration, was established in 1984 in the Faculty of Medicine, Khon Kaen University. Leukemia is the most common cancer among Thai children in Thailand, including both curable and preventable types, but no assessment of trends has hitherto been performed.
To perform a statistical assessment of the incidence trend of childhood leukemia in Khon Kaen, Thailand, between 1985 and 2002.
Population-based cases of childhood leukemia registered between 1985 and 2002 were retrieved from the KKCR and cases with an ICD-O diagnosis (coding C42) in children under 15 were selected. Incidence trends were calculated using the Generalized Linear Model method (GLM), which generates incidence-rate-based logarithms.
Of the 277 cases of leukemia, boys were affected two times more frequently than girls and half of the cases were 0-4 years of age. Most diagnoses were histologically- or cytologically-proven and the most common type (affecting two-thirds, 65.7%) was acute lymphoblastic leukemia (ALL). The overall, age-standardized rate (ASR) for leukemia was 31.9 per million (95%CI: 28.1 to 35.7); 40.3 per million (95%CI: 34.2 to 46.4) in boys and 27.0 (95%CI: 21.8 to 32.2) in girls. Incidence has been increasing by 2.4% per year in boys (95% CI: -0.5 to 5.3) and 4.1% per year in girls (95% CI: 1.1 to 7.2).
This incidence-rate-based logarithm indicates that childhood leukemia has been increasing, suggesting further epidemiological research on causes and possible prevention is needed.
孔敬癌症登记处（KKCR）于1984年在孔敬大学医学院成立，提供基于医院和人群的登记服务。白血病是泰国儿童中最常见的癌症，包括可治愈和可预防的类型，但迄今为止尚未对其趋势进行评估。
对1985年至2002年泰国孔敬儿童白血病的发病趋势进行统计评估。
从KKCR中检索1985年至2002年登记的基于人群的儿童白血病病例，并选择15岁以下儿童中ICD - O诊断（编码C42）的病例。使用广义线性模型方法（GLM）计算发病趋势，该方法生成基于发病率的对数。
在277例白血病病例中，男孩受影响的频率是女孩的两倍，一半的病例年龄在0至4岁之间。大多数诊断经组织学或细胞学证实，最常见的类型（占三分之二，65.7%）是急性淋巴细胞白血病（ALL）。白血病的总体年龄标准化率（ASR）为每百万31.9例（95%CI：28.1至35.7）；男孩为每百万40.3例（95%CI：34.2至46.4），女孩为每百万27.0例（95%CI：21.8至32.2）。男孩的发病率每年增加2.4%（95%CI： - 0.5至5.3），女孩每年增加4.1%（95%CI：1.1至7.2）。
这种基于发病率的对数表明儿童白血病一直在增加，这表明需要对病因和可能的预防措施进行进一步的流行病学研究。
