Department of Hematology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhufeng Avenue 1439, Zhuhai, 519000, China.
BMC Med Genomics. 2021 Sep 18;14(1):229. doi: 10.1186/s12920-021-01076-w.
Presently, whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial. Because of this reason, the objective of current study is to explore whether XRCC3 Thr241Met polymorphism confers risk to leukemia.
Two independent authors systematically and comprehensively searched Pubmed, Embase, the Cochrane library, Google academic, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021.
Overall, significant associations between leukemia risk and XRCC3 Thr241Met polymorphism were found in Caucasian population by allele contrast (T vs. C: OR 1.20, 95% CI 1.02-1.40), homozygote comparison (TT vs. CC: OR 1.35, 95% CI 1.05-1.73), and recessive genetic model (TT vs. TC/CC: OR 1.31, 95% CI 1.04-1.64).
The present meta-analysis suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for leukemia in Caucasian population.
目前，X 射线修复交叉互补基因 3（XRCC3）Thr241Met 多态性是否与白血病风险相关仍存在争议。基于此，本研究旨在探讨 XRCC3 Thr241Met 多态性是否与白血病风险相关。
两位作者独立地系统、全面地检索了 Pubmed、Embase、Cochrane 图书馆、Google 学术、中国知网（CNKI）。检索时间从数据库建立到 2021 年 3 月。
总体而言，等位基因对比（T 对 C：OR 1.20，95%CI 1.02-1.40）、纯合子比较（TT 对 CC：OR 1.35，95%CI 1.05-1.73）和隐性遗传模型（TT 对 TC/CC：OR 1.31，95%CI 1.04-1.64）均表明 XRCC3 Thr241Met 多态性与白血病风险在高加索人群中存在显著关联。
本荟萃分析表明，XRCC3 Thr241Met 多态性可能是高加索人群白血病的一个危险因素。
