Schweigreiter Rüdiger, Bandtlow Christine E
Biocenter Innsbruck, Division of Neurobiochemistry, Innsbruck, Austria.
J Neurotrauma. 2006 Mar-Apr;23(3-4):384-96. doi: 10.1089/neu.2006.23.384.
Myelin of the adult mammalian central nervous system (CNS) has been attributed to suppress structural plasticity and to impede regenerating nerve fibers. Nogo-A is possibly the best characterized of a variety of neurite growth inhibitors present in CNS myelin. Neutralizing its activity results in improved axon regrowth and functional recovery in experimental CNS lesion models of adult rodents and primates. While Nogo-A has become a major target for therapeutic intervention to promote axon regeneration in the CNS, it is realized that such an approach will likely have to be combined with other therapeutic strategies to maximize functional recovery after spinal cord injury (SCI).
成年哺乳动物中枢神经系统（CNS）的髓磷脂被认为会抑制结构可塑性并阻碍神经纤维再生。Nogo-A可能是中枢神经系统髓磷脂中存在的多种神经突生长抑制剂中特征最明确的一种。在成年啮齿动物和灵长类动物的实验性中枢神经系统损伤模型中，中和其活性可改善轴突再生和功能恢复。虽然Nogo-A已成为促进中枢神经系统轴突再生的治疗干预的主要靶点，但人们意识到，这种方法可能必须与其他治疗策略相结合，以最大限度地促进脊髓损伤（SCI）后的功能恢复。
