蛛网膜下腔出血后脑脊液中ST2蛋白水平升高。
Elevation of ST2 protein levels in cerebrospinal fluid following subarachnoid hemorrhage.
作者信息
Kanda M, Ohto-Ozaki H, Kuroiwa K, Tominaga S, Watanabe E, Iwahana H
机构信息
Department of Surgical Neurology, Jichi Medical School, Tochigi, Japan.
出版信息
Acta Neurol Scand. 2006 May;113(5):327-33. doi: 10.1111/j.1600-0404.2006.00587.x.
OBJECTIVE
To study the mode of appearance of ST2 in cerebrospinal fluid (CSF) after subarachnoid hemorrhage (SAH).
MATERIALS AND METHODS
Immunoprecipitation and subsequent immunoblotting were performed to reveal the existence of ST2 in CSF after SAH. CSF samples from 21 patients were analyzed for ST2 using an enzyme-linked immunosorbent assay system. The ST2 levels were compared between serum and CSF after SAH. The ST2 levels in CSF were measured in six patients operated with other than SAH.
RESULTS
ST2 was secreted into CSF after SAH. The concentration of ST2 was the highest in the samples of the first post-operative day and declined thereafter. The patients operated with other than SAH did not show the elevation of ST2 in CSF.
CONCLUSIONS
This study revealed the presence of ST2 in CSF for the first time and suggested a possibility that ST2 is related to the inflammatory reaction in the central nervous system after SAH.
目的
研究蛛网膜下腔出血（SAH）后脑脊液（CSF）中ST2的出现模式。
材料与方法
采用免疫沉淀及后续免疫印迹法揭示SAH后CSF中ST2的存在情况。使用酶联免疫吸附测定系统分析21例患者的CSF样本中的ST2。比较SAH后血清和CSF中的ST2水平。对6例非SAH手术患者的CSF中的ST2水平进行了测量。
结果
SAH后ST2分泌至CSF中。ST2浓度在术后第一天的样本中最高，此后下降。非SAH手术患者的CSF中未显示ST2升高。
结论
本研究首次揭示了CSF中存在ST2，并提示ST2可能与SAH后中枢神经系统的炎症反应有关。
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