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IL-33 在疾病中的作用：IL-1 家族的新成员。

Disease-associated functions of IL-33: the new kid in the IL-1 family.

机构信息

Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.

出版信息

Nat Rev Immunol. 2010 Feb;10(2):103-10. doi: 10.1038/nri2692. Epub 2010 Jan 18.

DOI:10.1038/nri2692
PMID:20081870
Abstract

Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T(H)2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.

摘要

白细胞介素-33（IL-33）是 IL-1 家族的新成员，在受到促炎刺激后，许多细胞类型都会表达这种细胞因子，并被认为在细胞溶解时释放。IL-33 受体由 ST2 和白细胞介素-1 受体辅助蛋白组成，也广泛表达，特别是在辅助性 T 细胞 2（T(H)2）细胞和肥大细胞中。IL-33 对寄生虫感染具有宿主保护作用，并通过促进 T(H)2 型免疫反应来减少动脉粥样硬化。然而，IL-33 也可以通过扩张 T(H)2 细胞和通过肥大细胞激活来介导关节炎症、特应性皮炎和过敏反应，从而促进哮喘的发病机制。因此，IL-33 可能成为治疗一系列疾病的新靶点。

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本文引用的文献

[1]
IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation.

J Immunol. 2009-11-15

[2]
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

J Immunol. 2009-10-15

[3]
Mature interleukin-33 is produced by calpain-mediated cleavage in vivo.

Biochem Biophys Res Commun. 2009-9-11

[4]
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.

Immunity. 2009-7-17

[5]
IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex.

J Immunol. 2009-7-15

[6]
Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma.

Biochem Biophys Res Commun. 2009-8-14

[7]
The cytokine interleukin-33 mediates anaphylactic shock.

Proc Natl Acad Sci U S A. 2009-6-16

[8]
Interleukin-33 is biologically active independently of caspase-1 cleavage.

J Biol Chem. 2009-7-17

[9]
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1.

Proc Natl Acad Sci U S A. 2009-6-2

[10]
IL-33-activated dendritic cells induce an atypical TH2-type response.

J Allergy Clin Immunol. 2009-5

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