IL-33 在疾病中的作用：IL-1 家族的新成员。
Disease-associated functions of IL-33: the new kid in the IL-1 family.
机构信息
Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, 120 University Place, Glasgow G12 8TA, UK.
出版信息
Nat Rev Immunol. 2010 Feb;10(2):103-10. doi: 10.1038/nri2692. Epub 2010 Jan 18.
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The IL-33 receptor, consisting of ST2 and IL-1 receptor accessory protein, is also widely expressed, particularly by T helper 2 (T(H)2) cells and mast cells. IL-33 is host-protective against helminth infection and reduces atherosclerosis by promoting T(H)2-type immune responses. However, IL-33 can also promote the pathogenesis of asthma by expanding T(H)2 cells and mediate joint inflammation, atopic dermatitis and anaphylaxis by mast cell activation. Thus IL-33 could be a new target for therapeutic intervention across a range of diseases.
白细胞介素-33（IL-33）是 IL-1 家族的新成员，在受到促炎刺激后，许多细胞类型都会表达这种细胞因子，并被认为在细胞溶解时释放。IL-33 受体由 ST2 和白细胞介素-1 受体辅助蛋白组成，也广泛表达，特别是在辅助性 T 细胞 2（T(H)2）细胞和肥大细胞中。IL-33 对寄生虫感染具有宿主保护作用，并通过促进 T(H)2 型免疫反应来减少动脉粥样硬化。然而，IL-33 也可以通过扩张 T(H)2 细胞和通过肥大细胞激活来介导关节炎症、特应性皮炎和过敏反应，从而促进哮喘的发病机制。因此，IL-33 可能成为治疗一系列疾病的新靶点。
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