Rieff Heather I, Corfas Gabriel
Neurobiology Program, Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA 02115, USA.
Eur J Neurosci. 2006 Apr;23(8):2225-9. doi: 10.1111/j.1460-9568.2006.04727.x.
The formation of morphologically and functionally mature dendrites is a key event in neuronal maturation and the establishment of functional neuronal networks, but the signals that regulate mammalian dendritic development remain poorly understood. Here we show that the erbB receptor signalling pathway, which modulates expression of several neurotransmitter receptors, also regulates dendritic development of cerebellar granule cells in the intact cerebellum. These results suggest that neuregulin-erbB signalling may control a program of postsynaptic development, from initiating dendrite morphogenesis to the formation and maturation of the postsynaptic apparatus.
形态和功能成熟的树突的形成是神经元成熟以及功能性神经网络建立过程中的关键事件，但调节哺乳动物树突发育的信号仍知之甚少。在此我们表明，调节多种神经递质受体表达的erbB受体信号通路，也在完整小脑中调节小脑颗粒细胞的树突发育。这些结果表明，神经调节蛋白-erbB信号可能控制着一个突触后发育程序，从启动树突形态发生到突触后装置的形成和成熟。
