皮肤淋巴瘤的发病机制与治疗——进展还是僵局？

Pathogenesis and therapy of cutaneous lymphomas--progress or impasse?

作者信息

Dummer Reinhard, Cozzio Antonio, Urosevic Mirjana

机构信息

Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.

出版信息

Exp Dermatol. 2006 May;15(5):392-400. doi: 10.1111/j.0906-6705.2006.00419.x.

DOI:10.1111/j.0906-6705.2006.00419.x

PMID:16630081

Abstract

The cutaneous environment hosts a number of hematopoietic neoplasms that are dominated by primary cutaneous (PC) T-cell lymphomas. Recent progress in molecular biology and immunology has provided tools to investigate the pathogenesis and the biology of these neoplasms. This review highlights newest findings concerning the immune biology of CD4+ CD56+ hematodermic neoplasms, and PC T-cell and B-cell lymphomas, speculating how these can be translated into more sophisticated, biology-based treatment approaches in the near future.

摘要

皮肤环境中存在多种造血系统肿瘤，其中原发性皮肤（PC）T细胞淋巴瘤占主导地位。分子生物学和免疫学的最新进展为研究这些肿瘤的发病机制和生物学特性提供了工具。本综述重点介绍了有关CD4 + CD56 +血液皮肤肿瘤以及PC T细胞和B细胞淋巴瘤免疫生物学的最新发现，并推测在不久的将来如何将这些发现转化为更复杂的、基于生物学的治疗方法。