原发性皮肤B细胞淋巴瘤：手术的作用
Primary cutaneous B-cell lymphoma: Role of surgery.
作者信息
Parbhakar Sam, Cin Arianna Dal
机构信息
Division of Plastic Surgery.
出版信息
Can J Plast Surg. 2011 Summer;19(2):e12-4.
PURPOSE
To evaluate the role of surgery in patients diagnosed with primary cutaneous B-cell lymphoma (PCBCL) - a rare disease entity. The authors offer a rationale for the use of primary surgical excision in the treatment of isolated cutaneous lymphomas.
METHODS
A literature review examining the use of primary surgical excision in the treatment of PCBCL was conducted. The lymphoma database at the Juravinski Cancer Centre (Hamilton, Ontario) was searched from January 1995 to July 2008, generating a list of 4924 patients. A simulated computer program was subsequently designed to search for all possible PCBCLs. A retrospective chart review was then conducted on the new list of 1325 patients, identifying 25 patients diagnosed with PCBCL.
RESULTS
The mean age of the 25 patients with PCBCL was 59.9 years; nine (36%) were treated with surgery, and sixteen (64%) with radiation. The average follow-up period for patients was 3.6 years. Twenty-four of the 25 patients were completely cured, with only one patient recurring in the radiation subgroup. There were no complications in the surgery subgroup. There were two local complications in the radiation subgroup consisting of chronic ulcerations.
CONCLUSIONS
Primary surgical excision is an effective management option in the treatment of PCBCL, particularly the marginal zone and follicle centre subtypes.
目的
评估手术在原发性皮肤B细胞淋巴瘤（PCBCL）患者（一种罕见的疾病实体）中的作用。作者为原发性手术切除在孤立性皮肤淋巴瘤治疗中的应用提供了理论依据。
方法
进行了一项文献综述，研究原发性手术切除在PCBCL治疗中的应用。检索了1995年1月至2008年7月期间朱拉温斯基癌症中心（安大略省汉密尔顿）的淋巴瘤数据库，共产生4924名患者的列表。随后设计了一个模拟计算机程序来搜索所有可能的PCBCL病例。然后对新的1325名患者列表进行回顾性病历审查，确定25名被诊断为PCBCL的患者。
结果
25例PCBCL患者的平均年龄为59.9岁；9例（36%）接受了手术治疗，16例（64%）接受了放疗。患者的平均随访期为3.6年。25例患者中有24例完全治愈，仅1例在放疗亚组中复发。手术亚组无并发症。放疗亚组有2例局部并发症，均为慢性溃疡。
结论
原发性手术切除是治疗PCBCL的一种有效管理选择，尤其是边缘区和滤泡中心亚型。
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