Kaneda Yasufumi, Tabata Yasuhiko
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
Cancer Sci. 2006 May;97(5):348-54. doi: 10.1111/j.1349-7006.2006.00189.x.
Cancers are diverse and often resistant to therapeutic strategies. Gene therapy has yet to meet the promise of a breakthrough in cancer therapy. There are several barriers to overcome in cancer gene therapy. One of the biggest challenges is the design of appropriate vectors. Numerous viral and non-viral methods for gene transfer have been developed for human gene therapy, but both viral and non-viral vectors have limitations and advantages. In this review article, recent improvements in the development of non-viral vectors for delivering gene therapy for the treatment of cancer will be discussed.
癌症具有多样性，并且常常对治疗策略产生抗性。基因治疗尚未实现癌症治疗取得突破性进展的承诺。癌症基因治疗存在若干需要克服的障碍。最大的挑战之一是设计合适的载体。已经开发出许多用于人类基因治疗的病毒和非病毒基因转移方法，但病毒和非病毒载体都有其局限性和优点。在这篇综述文章中，将讨论用于癌症治疗的基因治疗非病毒载体开发方面的最新进展。
