用于癌症治疗的非病毒载体。
Non-viral vectors for cancer therapy.
作者信息
Kaneda Yasufumi, Tabata Yasuhiko
机构信息
Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
出版信息
Cancer Sci. 2006 May;97(5):348-54. doi: 10.1111/j.1349-7006.2006.00189.x.
Abstract
Cancers are diverse and often resistant to therapeutic strategies. Gene therapy has yet to meet the promise of a breakthrough in cancer therapy. There are several barriers to overcome in cancer gene therapy. One of the biggest challenges is the design of appropriate vectors. Numerous viral and non-viral methods for gene transfer have been developed for human gene therapy, but both viral and non-viral vectors have limitations and advantages. In this review article, recent improvements in the development of non-viral vectors for delivering gene therapy for the treatment of cancer will be discussed.
摘要
癌症具有多样性，并且常常对治疗策略产生抗性。基因治疗尚未实现癌症治疗取得突破性进展的承诺。癌症基因治疗存在若干需要克服的障碍。最大的挑战之一是设计合适的载体。已经开发出许多用于人类基因治疗的病毒和非病毒基因转移方法，但病毒和非病毒载体都有其局限性和优点。在这篇综述文章中，将讨论用于癌症治疗的基因治疗非病毒载体开发方面的最新进展。
相似文献
1
Non-viral vectors for cancer therapy.用于癌症治疗的非病毒载体。
Cancer Sci. 2006 May;97(5):348-54. doi: 10.1111/j.1349-7006.2006.00189.x.
2
Pulmonary gene delivery-Realities and possibilities.肺部基因传递——现实与可能性。
Exp Biol Med (Maywood). 2021 Feb;246(3):260-274. doi: 10.1177/1535370220965985. Epub 2020 Nov 12.
3
Molecular therapeutics of cancer by means of electroporation-based transfer of siRNAs and EBV-based expression vectors.通过基于电穿孔的小干扰RNA转移和基于EB病毒的表达载体进行癌症的分子治疗。
Front Biosci (Elite Ed). 2009 Jun 1;1(1):316-31. doi: 10.2741/E31.
4
Electroporation as a method for the efficient in vivo delivery of therapeutic genes.电穿孔作为一种在体内有效递送治疗性基因的方法。
DNA Cell Biol. 2003 Dec;22(12):753. doi: 10.1089/104454903322624957.
5
Engineered Non-Viral Gene Vectors for Combination Cancer Therapy: A Review.用于联合癌症治疗的工程化非病毒基因载体：综述
J Biomed Nanotechnol. 2017 Dec 1;13(12):1565-1580. doi: 10.1166/jbn.2017.2489.
6
Gene therapy using HVJ-liposomes: the best of both worlds?使用HVJ脂质体的基因治疗：两全其美？
Mol Med Today. 1999 Jul;5(7):298-303. doi: 10.1016/s1357-4310(99)01482-3.
7
HVJ-based non-viral gene transfer method: successful gene therapy using HGF and VEGF genes in experimental ischemia.基于仙台病毒的非病毒基因转移方法：在实验性缺血中使用肝细胞生长因子和血管内皮生长因子基因进行成功的基因治疗。
Front Biosci. 2006 Jan 1;11:753-9. doi: 10.2741/1833.
8
Non-viral delivery of RNA interference targeting cancer cells in cancer gene therapy.非病毒载体 RNA 干扰在肿瘤基因治疗中靶向癌细胞。
Curr Gene Ther. 2012 Aug;12(4):275-84. doi: 10.2174/156652312802083576.
9
Polymeric vectors for ocular gene delivery.用于眼部基因递送的聚合物载体。
Ther Deliv. 2011 Apr;2(4):523-36. doi: 10.4155/tde.11.20.
10
Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects.基因治疗中的非病毒载体：最新进展、挑战与展望。
AAPS J. 2021 Jun 2;23(4):78. doi: 10.1208/s12248-021-00608-7.
引用本文的文献
1
Exploring AAV-Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential.探索腺相关病毒介导的内耳疾病基因治疗：从临床前成功到临床潜力
Adv Sci (Weinh). 2025 Sep;12(33):e08397. doi: 10.1002/advs.202408397. Epub 2025 Jun 20.
2
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy.在利用病毒和非病毒载体传递用于癌症治疗的遗传和非遗传货物方面的技术进展。
Drug Deliv Transl Res. 2023 Nov;13(11):2719-2738. doi: 10.1007/s13346-023-01362-3. Epub 2023 Jun 10.
3
A novel peptide ligand-coated nano-siRNA-lipoplex technology for kidney targeted gene therapy.一种用于肾脏靶向基因治疗的新型肽配体包被的纳米小干扰RNA脂质复合物技术。
Am J Transl Res. 2022 Oct 15;14(10):7362-7377. eCollection 2022.
4
Targeted Liposomes: A Nonviral Gene Delivery System for Cancer Therapy.靶向脂质体：一种用于癌症治疗的非病毒基因递送系统。
Pharmaceutics. 2022 Apr 8;14(4):821. doi: 10.3390/pharmaceutics14040821.
5
Engineering Circulating Tumor Cells as Novel Cancer Theranostics.工程化循环肿瘤细胞作为新型癌症治疗与诊断一体化策略。
Theranostics. 2020 Jun 29;10(17):7925-7937. doi: 10.7150/thno.44259. eCollection 2020.
6
A novel method for conjugating the terminal amine of peptide ligands to cholesterol: synthesis iRGD-cholesterol.一种将肽配体的末端胺与胆固醇偶联的新方法：合成iRGD-胆固醇。
Ther Deliv. 2019 Jan;10(1):11-20. doi: 10.4155/tde-2018-0057.
7
Cationic cholesterol derivative efficiently delivers the genes: in silico and in vitro studies.阳离子胆固醇衍生物高效传递基因：计算机模拟和体外研究。
Drug Deliv Transl Res. 2019 Feb;9(1):106-122. doi: 10.1007/s13346-018-0571-z.
8
Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.Rad51高表达预示结直肠癌预后不良：我们对54例患者的经验
PLoS One. 2017 Jan 18;12(1):e0167868. doi: 10.1371/journal.pone.0167868. eCollection 2017.
9
Lipothioureas as Lipids for Gene Transfection: A Review.作为用于基因转染的脂质的硫脲类化合物：综述
Pharmaceuticals (Basel). 2011 Oct 24;4(10):1381-1399. doi: 10.3390/ph4101381.
10
Antitumor and antimetastasis effects of carboplatin liposomes with polyethylene glycol-2000 on SGC-7901 gastric cell-bearing nude mice.聚乙二醇-2000修饰的卡铂脂质体对荷SGC-7901胃癌细胞裸鼠的抗肿瘤及抗转移作用
Oncol Lett. 2014 Nov;8(5):2209-2214. doi: 10.3892/ol.2014.2494. Epub 2014 Sep 3.
本文引用的文献
1
Assembly of variant histones into chromatin.变异组蛋白组装进入染色质。
Annu Rev Cell Dev Biol. 2005;21:133-53. doi: 10.1146/annurev.cellbio.21.012704.133518.
2
Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector.具有表面修饰的磁性纳米颗粒增强了HVJ-E载体的基因递送。
Biochem Biophys Res Commun. 2005 Sep 9;334(4):1121-6. doi: 10.1016/j.bbrc.2005.06.204.
3
Eradication of hepatocellular carcinoma xenografts by radiolabelled, lipiodol-inducible gene therapy.放射性标记的、碘油诱导基因疗法对肝癌异种移植瘤的根除作用
Gene Ther. 2005 Nov;12(22):1633-9. doi: 10.1038/sj.gt.3302531.
4
Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study.异环磷酰胺/脂质体柔红霉素是一种耐受性良好且有效的晚期软组织肉瘤一线化疗方案：一项II期研究结果
Cancer. 2005 Aug 1;104(3):611-7. doi: 10.1002/cncr.21211.
5
Structural and sequence motifs of protein (histone) methylation enzymes.蛋白质（组蛋白）甲基化酶的结构和序列基序。
Annu Rev Biophys Biomol Struct. 2005;34:267-94. doi: 10.1146/annurev.biophys.34.040204.144452.
6
Enhanced intracellular mobility and nuclear accumulation of DNA plasmids associated with a karyophilic protein.与亲核蛋白相关的DNA质粒细胞内移动性增强及核内积累。
Hum Gene Ther. 2005 Feb;16(2):200-8. doi: 10.1089/hum.2005.16.200.
7
Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin.由HVJ包膜载体递送的Rad51小干扰RNA增强顺铂的抗癌效果。
J Gene Med. 2005 Aug;7(8):1044-52. doi: 10.1002/jgm.753.
8
Use of liposomal anthracyclines in Kaposi's sarcoma.脂质体蒽环类药物在卡波西肉瘤中的应用。
Semin Oncol. 2004 Dec;31(6 Suppl 13):36-52. doi: 10.1053/j.seminoncol.2004.08.003.
9
Biocompatible polymer enhances the in vitro and in vivo transfection efficiency of HVJ envelope vector.生物相容性聚合物提高了HVJ包膜载体的体外和体内转染效率。
J Gene Med. 2005 Jul;7(7):888-97. doi: 10.1002/jgm.735.
10
Gene therapy progress and prospects: electroporation and other physical methods.基因治疗的进展与前景：电穿孔及其他物理方法
Gene Ther. 2004 Sep;11(18):1363-9. doi: 10.1038/sj.gt.3302337.
Zotero 插件