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Rad51高表达预示结直肠癌预后不良：我们对54例患者的经验

Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients.

作者信息

Li Yan, Wang Wei-Ya, Xiao Jiang-Hong, Xu Feng, Liao Dian-Ying, Xie Li, Wang Jin, Luo Feng

机构信息

Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Department of Pathology, West China Hospital, Sichuan University, Chengdu, China.

出版信息

PLoS One. 2017 Jan 18;12(1):e0167868. doi: 10.1371/journal.pone.0167868. eCollection 2017.

DOI:10.1371/journal.pone.0167868
PMID:28099437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5242438/
Abstract

BACKGROUND

Aberrant Rad51 expression is implicated in the progression of human malignancies. However, the role of Rad51 in colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between Rad51 and clinicopathologic features of CRC.

METHODS

We retrospectively examined the paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgical therapies at our institution during 2006-2008. Rad51 expression in adenocarcinoma, paracancerous tissue, and normal colonic tissue was determined by immunohistochemistry. The correlation between Rad51 immunoreactivity and clinicopathologic features of these patients was evaluated.

RESULTS

Rad51 immunoreactivity was detected in 67% of adenocarcinoma, 48% of paracancerous tissue, and 27% of normal colonic mucosa. Rad51 expression in adenocarcinoma was significantly higher than normal colonic tissue (p < 0.05). Rad51 was also overexpressed in poorly differentiated tumors and tumor samples from patients with lymph node metastasis (p < 0.05). Patients with Rad51 overexpression had a 69% two-year survival, 49% three-year survival, and 16% five-year survival, considerably worse than patients with negative Rad51 expression (p < 0.05).

CONCLUSION

Our data suggest that Rad51 overexpression is correlated with malignant phenotypes of CRC and may predict poor prognosis for these patients.

摘要

背景

Rad51表达异常与人类恶性肿瘤的进展有关。然而，Rad51在结直肠癌（CRC）中的作用仍不明确。本研究旨在建立Rad51与CRC临床病理特征之间的关系。

方法

我们回顾性检查了2006 - 2008年期间在我院接受手术治疗的54例CRC患者的石蜡包埋组织样本。通过免疫组织化学法测定腺癌、癌旁组织和正常结肠组织中Rad51的表达。评估这些患者Rad51免疫反应性与临床病理特征之间的相关性。

结果

在67%的腺癌、48%的癌旁组织和27%的正常结肠黏膜中检测到Rad51免疫反应性。腺癌中Rad51的表达显著高于正常结肠组织（p < 0.05）。Rad51在低分化肿瘤以及有淋巴结转移患者的肿瘤样本中也过表达（p < 0.05）。Rad51过表达的患者两年生存率为69%，三年生存率为49%，五年生存率为16%，明显低于Rad51表达阴性的患者（p < 0.05）。

结论

我们的数据表明，Rad51过表达与CRC的恶性表型相关，可能预示这些患者预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/4c1dd4d2eeaa/pone.0167868.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/16b072232976/pone.0167868.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/ae31eba115a5/pone.0167868.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/fe8fb5240ee6/pone.0167868.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/4c1dd4d2eeaa/pone.0167868.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/16b072232976/pone.0167868.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/ae31eba115a5/pone.0167868.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/fe8fb5240ee6/pone.0167868.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7d0/5242438/4c1dd4d2eeaa/pone.0167868.g004.jpg

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