伴有假上皮瘤样增生的口腔恶性黑色素瘤。病例报告。
Oral malignant melanoma associated with pseudoepitheliomatous hyperplasia. Report of a case.
作者信息
Meleti Marco, Mooi Wolter J, van der Waal Isaäc
机构信息
Unit of Oral Pathology and Medicine, Section of Odontostomatology, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Parma, Italy.
出版信息
J Cutan Pathol. 2006 Apr;33(4):331-3. doi: 10.1111/j.0303-6987.2006.00454.x.
BACKGROUND
Pseudoepitheliomatous hyperplasia (PEH), a histological mimic of squamous cell carcinoma, is an exuberant reactive epithelial proliferation that may be induced by a variety of infectious, traumatic, inflammatory and neoplastic conditions of the skin and mucous membranes. PEH has been described in association with Spitz nevi and intramucosal nevi but not with oral malignant melanoma.
METHODS AND RESULTS
A case of PEH in malignant melanoma of the palate in a 46-year-old female patient has been described. A search of the English literature did not disclose any previously reported case of such event.
CONCLUSIONS
PEH associated with oral malignant melanoma is apparently very rare and most likely originates from the surface epithelium. This is in contrast with PEH in cutaneous melanoma where follicular or eccrine units have been suggested to be the origin.
背景
假上皮瘤样增生（PEH）是鳞状细胞癌的一种组织学模拟病变，是一种旺盛的反应性上皮增生，可由皮肤和黏膜的多种感染性、创伤性、炎症性和肿瘤性疾病诱发。PEH已被描述与Spitz痣和黏膜内痣相关，但与口腔恶性黑色素瘤无关。
方法与结果
本文描述了一名46岁女性患者腭部恶性黑色素瘤合并PEH的病例。检索英文文献未发现此前有此类事件的报道。
结论
与口腔恶性黑色素瘤相关的PEH显然非常罕见，很可能起源于表面上皮。这与皮肤黑色素瘤中的PEH形成对比，后者曾被认为起源于毛囊或汗腺单位。
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