Ozyürek E, Cetintaş S, Ceylan T, Oğüş E, Haberal A, Gürakan B, Ozbek N
Hematology Section, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
Clin Lab Haematol. 2006 Apr;28(2):97-104. doi: 10.1111/j.1365-2257.2006.00767.x.
No previous study has investigated the full range of complete blood count (CBC) parameters in small-for-gestational-age (SGA) newborns. The main aim of this study was to compare CBC and peripheral smear parameters in term, healthy SGA neonates and appropriate-for-gestational-age (AGA) neonates, and to establish CBC reference values for full-term SGA newborns. One hundred thirty-two healthy, term newborns (73 SGA and 59 AGA) were included. On day 1, we obtained 109 samples and on day 7 we obtained 77 samples. A CBC and peripheral smear were analyzed for each sample collected and group data were compared. We observed higher mean values for normoblast count, hemoglobin, hematocrit, and red blood cell (RBC) count in the SGA babies than in the AGA babies on day 1. The mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration values for the SGA babies were decreased because of the relatively high RBC count and relatively high mean corpuscular volume we observed in this group. Of the SGA newborns, 21.9% had neutropenia and 4.7% had absolute neutrophil counts lower than 1500/microl on day 1. On both day 1 and day 7, the SGA newborns had higher mean absolute metamyelocyte counts and higher mean I : T (immature : total neutrophil ratio) values than the AGA group. The SGA babies had a lower mean absolute lymphocyte count on day 7 than the AGA group. We detected thrombocytopenia in almost one-third of the 64 SGA newborns tested on day 1. In summary, our study clearly demonstrates that CBC parameters for healthy, full-term, SGA newborns are different from those of healthy, term AGA newborns. This is the first study that has documented different mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, metamyelocyte counts, lymphocyte counts, and I : T in SGA babies compared with AGA babies.
此前尚无研究对小于胎龄（SGA）新生儿的全血细胞计数（CBC）参数进行全面调查。本研究的主要目的是比较足月健康SGA新生儿和适于胎龄（AGA）新生儿的CBC及外周血涂片参数，并建立足月SGA新生儿的CBC参考值。研究纳入了132名健康足月新生儿（73名SGA和59名AGA）。第1天获取了109份样本，第7天获取了77份样本。对采集的每个样本进行CBC和外周血涂片分析，并比较组间数据。我们观察到，第1天时SGA婴儿的早幼红细胞计数、血红蛋白、血细胞比容和红细胞（RBC）计数的平均值高于AGA婴儿。由于我们在该组中观察到相对较高的RBC计数和相对较高的平均红细胞体积，SGA婴儿的平均红细胞血红蛋白和平均红细胞血红蛋白浓度值降低。在第1天，21.9%的SGA新生儿有中性粒细胞减少症，4.7%的新生儿绝对中性粒细胞计数低于1500/微升。在第1天和第7天，SGA新生儿的平均晚幼粒细胞绝对计数和平均I:T（未成熟:总中性粒细胞比率）值均高于AGA组。第7天时，SGA婴儿的平均绝对淋巴细胞计数低于AGA组。在第1天接受检测的64名SGA新生儿中，近三分之一检测到血小板减少症。总之，我们的研究清楚地表明，健康足月SGA新生儿的CBC参数与健康足月AGA新生儿不同。这是第一项记录SGA婴儿与AGA婴儿相比，平均红细胞体积、平均红细胞血红蛋白、平均红细胞血红蛋白浓度、晚幼粒细胞计数、淋巴细胞计数和I:T不同的研究。
