Department of Neonatology, Medical University of Bialystok, Bialystok, Poland.
Adv Med Sci. 2011;56(2):361-5. doi: 10.2478/v10039-011-0030-2.
The current study objective was to compare blood platelet indices in full-term small-for-gestational-age newborns (SGA) and full-term appropriate-for-gestational-age newborns (AGA).
MATERIALS/METHODS: We introduced to our study 61 SGA newborns (31 females and 30 males) and 70 eutrophic infants (32 females and 38 males). The SGA newborns were divided into two groups: those weighing less than the 5th centile: 35 infants (16 females and 19 males) and those between the 5th and 10th centiles: 26 infants (15 females and 11 males). Platelet indices were estimated in blood samples collected from the umbilical artery.
SGA demonstrated a decreased count of blood platelets (238×103/μ) as compared with AGA (286×103/μL), p=0.0001. Platelet hematocrit (PTC) also showed differences in both groups (SGA=0.19% vs. AGA=0.22%; p=0.0005). Mean platelet volume (MPV) was higher in SGA (8.25fl) as compared with AGA (7.84fl); p=0.008. Large platelet count (LPLT) was higher in AGA 6.26% vs. SGA=4.75%; p=0.01. Platelet distribution width (PDW) was found to be nearly the same (SGA=47%, AGA=46%). PDW was higher in SGA newborns < 5th centile (43%) as compared with SGA infants between the 5th and 10th centiles (52%); p=0.008.
A decreased blood platelet count, platelet hematocrit and large metabolically active platelet count, which in addition to reduced synthesis and excessive consumption of coagulation factors in states of hiperclotting is characteristic of IUGR, enhances the possibility of bleeding complications and increases the risk of infections. From a clinical point of view, it is important to take into consideration the degree of intrauterine hypotrophy during the evaluation of hemostatic disorders.
本研究旨在比较足月小于胎龄儿（SGA）和足月适于胎龄儿（AGA）的血小板指数。
材料/方法：我们将 61 例 SGA 新生儿（31 名女性和 30 名男性）和 70 名营养正常的婴儿（32 名女性和 38 名男性）纳入研究。SGA 新生儿分为两组：体重低于第 5 百分位的新生儿 35 例（16 名女性和 19 名男性）和体重在第 5 至第 10 百分位之间的新生儿 26 例（15 名女性和 11 名男性）。在采集的脐动脉血样中估算血小板指数。
与 AGA（286×103/μL）相比，SGA 显示血小板计数减少（238×103/μ），p=0.0001。血小板比容（PTC）在两组中也存在差异（SGA=0.19% vs. AGA=0.22%；p=0.0005）。与 AGA（7.84fl）相比，SGA 的平均血小板体积（MPV）更高（8.25fl）；p=0.008。SGA 中的大血小板计数（LPLT）更高（6.26%），AGA 中 LPLT 为 4.75%；p=0.01。血小板分布宽度（PDW）几乎相同（SGA=47%，AGA=46%）。与第 5 至 10 百分位的 SGA 新生儿相比，SGA 新生儿中小于第 5 百分位的新生儿的 PDW 更高（43%）；p=0.008。
血小板计数、血小板比容和大代谢活跃血小板计数减少，再加上高凝状态下凝血因子合成减少和过度消耗，是宫内生长受限（IUGR）的特征，增加了出血并发症的可能性，并增加了感染的风险。从临床角度来看，在评估止血障碍时，考虑到宫内生长迟缓的程度很重要。
