Jun Z J, Ping T, Lei Y, Li L, Ming S Y, Jing W
China-Japan Union Hospital, Ji Lin University, Changchun, China.
Clin Lab Haematol. 2006 Apr;28(2):111-6. doi: 10.1111/j.1365-2257.2006.00757.x.
Venous thromboembolism (VTE) is a common vascular disease that results in two major clinical manifestations: deep venous thrombosis (DVT) and pulmonary embolism (PE). Several genetic risk factors, especially factor V Leiden and prothrombin G20210A mutations have been reported to be related to VTE in Caucasians, but the relationship remains controversial in other populations. Thus, the objective of the present study was to compare the frequency of the two mutations and also to investigate whether acquired risk factors other than genetic mutations may play a different role in Chinese VTE patients. Thirty-five patients were diagnosed with DVT concomitant PE, 178 patients with DVT, 54 patients with PE and 102 control subjects were recruited. The mutation was determined by the polymerase chain reaction-restriction fragment length polymorphism method. Of all subjects, none was a carrier of factor V Leiden or prothrombin G20210A mutations. The frequency of surgery was significantly higher in the PE group than that in other groups. There was no significant difference among the three groups in other known risk factors. The data presented here indicate that factor V Leiden and prothrombin G20210A mutations are very rare in the Chinese population, and the genetic risk profile of VTE in the Chinese population is different from that in Caucasians.
静脉血栓栓塞症（VTE）是一种常见的血管疾病，可导致两种主要临床表现：深静脉血栓形成（DVT）和肺栓塞（PE）。据报道，几种遗传危险因素，尤其是因子V莱顿突变和凝血酶原G20210A突变与白种人中的VTE有关，但在其他人群中这种关系仍存在争议。因此，本研究的目的是比较这两种突变的频率，并调查除基因突变外的获得性危险因素在中国VTE患者中是否可能发挥不同作用。招募了35例诊断为DVT合并PE的患者、178例DVT患者、54例PE患者和102例对照者。通过聚合酶链反应-限制性片段长度多态性方法确定突变。在所有受试者中，没有人是因子V莱顿或凝血酶原G20210A突变的携带者。PE组的手术频率显著高于其他组。在其他已知危险因素方面，三组之间没有显著差异。此处呈现的数据表明，因子V莱顿和凝血酶原G20210A突变在中国人群中非常罕见，并且中国人群中VTE的遗传风险特征与白种人不同。
