Vyas F L, Mathai V, Selvamani B, John S, Banerjee Jesudason S R
Department of Surgery Unit 2, Christian Medical College and Hospital, Vellore 632004, India.
Colorectal Dis. 2006 May;8(4):342-6. doi: 10.1111/j.1463-1318.2006.00950.x.
Radiation proctitis is a common complication following radiation therapy for pelvic malignancies. This is associated with significant morbidity which adversely affects the quality of life. Local application of formalin has been used effectively in the treatment of radiation proctitis.
Thirty patients with haemorrhagic radiation proctitis who underwent endoluminal application of 4% formalin between January 1998 to October 2002 were followed up prospectively to assess the efficacy of the treatment.
The follow up ranged from 5 to 36 months (mean 18.1 months). Nineteen (63.3%) patients had complete response to formalin application while 7 (23.3%) patients had partial response. There were 4 (13.3%) failures. No procedure related complication was observed.
Local application of formalin is a simple, safe, inexpensive and fairly effective outpatient treatment modality for chronic radiation proctitis.
放射性直肠炎是盆腔恶性肿瘤放射治疗后的常见并发症。这与严重的发病率相关，对生活质量产生不利影响。局部应用福尔马林已有效地用于放射性直肠炎的治疗。
对1998年1月至2002年10月间接受4%福尔马林腔内应用治疗的30例出血性放射性直肠炎患者进行前瞻性随访，以评估治疗效果。
随访时间为5至36个月（平均18.1个月）。19例（63.3%）患者对福尔马林应用完全缓解，7例（23.3%）患者部分缓解。有4例（13.3%）治疗失败。未观察到与手术相关的并发症。
局部应用福尔马林是一种简单、安全、廉价且相当有效的慢性放射性直肠炎门诊治疗方式。
