Nootheti Sailaja, Bielory Leonard
University of Medicine and Dentistry of New Jersey, 90 Bergen Street, Newark, NJ 07103, USA.
Compr Ophthalmol Update. 2006 Jan-Feb;7(1):31-9.
With the increasing use of inhaled corticosteroids as first-line therapy in the treatment of asthma, the adverse effects of these preparations have become the topic of much research in recent years. While it is known that orally administered steroids can have metabolic, musculoskeletal, dermatologic, hematologic, and ophthalmologic effects (inhaled corticosteroids have minimal reported hematologic or musculoskeletal effects, but have some effects on metabolic processes such as calcium metabolism), it is less understood whether or not, and at what doses, inhaled corticosteroids will effect the eye. A computerized literature search was performed to search for literature pertaining to the specific use of oral or inhaled (nasal or bronchial) steroids, adverse effects, side effects, long-term use, chronic use, glaucoma, ocular effects, and increased ocular pressure. The search focused on the effects of inhaled corticosteroids in both adults and children, but contained an emphasis on children; studies pertaining to the effects in children, however, are limited.
随着吸入性糖皮质激素在哮喘治疗中作为一线疗法的使用日益增加，近年来这些制剂的不良反应已成为大量研究的主题。虽然已知口服类固醇会产生代谢、肌肉骨骼、皮肤、血液和眼科方面的影响（吸入性糖皮质激素报告的血液或肌肉骨骼影响极小，但对诸如钙代谢等代谢过程有一些影响），但对于吸入性糖皮质激素是否会以及以何种剂量影响眼睛，人们了解较少。进行了计算机化文献检索，以查找与口服或吸入（鼻用或支气管用）类固醇的特定用途、不良反应、副作用、长期使用、慢性使用、青光眼、眼部影响和眼压升高相关的文献。该检索侧重于吸入性糖皮质激素在成人和儿童中的影响，但重点是儿童；然而，有关儿童影响的研究有限。
