Ieda Yasuhiro, Nagasaka Yukio
Kinki University Sakai Hospital, Department of Pulmonary Medicine.
Clin Calcium. 2007 Jun;17(6):955-62.
Inhalation and oral steroids therapy has been used in the management of asthma, chronic obstructive pulmonary disease (COPD) and interstitial lung disease. This article described the effects of inhaled corticosteroids on bone. Inhaled corticosteroids are the standard of therapy in asthma and are commonly prescribed for chronic obstructive pulmonary disease. Accumulating evidence suggests that the effect of inhaled corticosteroids on bone is not small. Recent studies have shown that long-term use of inhaled corticosteroid at moderate or high doses is also associated with increased risk for the effects of inhaled corticosteroids on bone. Older age, inmobility and steroid treatment are major risk factors of osteoporosis. Treatment with bisphosphonate will be recommended in these patients, so earlier prevention for corticosteroids induced osteoporosis is necessary at administration of inhaled corticosteroids.
吸入和口服类固醇疗法已用于哮喘、慢性阻塞性肺疾病（COPD）和间质性肺疾病的治疗。本文描述了吸入性皮质类固醇对骨骼的影响。吸入性皮质类固醇是哮喘治疗的标准药物，常用于慢性阻塞性肺疾病的治疗。越来越多的证据表明，吸入性皮质类固醇对骨骼的影响并不小。最近的研究表明，长期中等剂量或高剂量使用吸入性皮质类固醇也会增加其对骨骼产生影响的风险。年龄较大、活动不便和类固醇治疗是骨质疏松症的主要危险因素。对于这些患者，建议使用双膦酸盐进行治疗，因此在使用吸入性皮质类固醇时，有必要尽早预防皮质类固醇诱导的骨质疏松症。
