Brand Timothy C, Thibault Gregory P, Basler Joseph W
Department of Urology, University of Texas Health Science Center, Mail Code 7845, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Curr Urol Rep. 2006 May;7(3):186-92. doi: 10.1007/s11934-006-0020-2.
Most prostate biopsies do not show malignancy. The proper management of non-cancerous pathologic findings of the prostate is controversial. For this article, we reviewed the current literature for indications for repeat prostate biopsy after initial biopsies demonstrated non-cancerous prostatic tissue or benign prostatic hyperplasia. This review includes discussions of management of asymptomatic prostatitis and how it may affect prostate-specific antigen, and also the management of several potentially premalignant lesions such as atrophy, atypical small acinar proliferation, and high-grade prostatic intraepithelial neoplasia. There is a paucity of randomized trials in this area and, considering the high number of biopsies with non-malignant findings, we conclude that more investigation is warranted in this area.
大多数前列腺活检未显示恶性病变。前列腺非癌性病理结果的恰当处理存在争议。在本文中，我们回顾了当前文献，以了解初次活检显示为非癌性前列腺组织或良性前列腺增生后再次进行前列腺活检的指征。本综述包括对无症状前列腺炎的处理及其对前列腺特异性抗原可能产生的影响的讨论，以及对几种潜在的癌前病变（如萎缩、非典型小腺泡增生和高级别前列腺上皮内瘤变）的处理。该领域的随机试验较少，鉴于有大量活检结果为非恶性，我们得出结论，该领域需要更多研究。
