Spiess Philippe E, Leibovici Dan, Pisters Louis L
Department of Urology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1373, Houston, TX 77030, USA.
Curr Urol Rep. 2006 May;7(3):209-16. doi: 10.1007/s11934-006-0023-z.
Locally advanced prostate cancer is diagnosed in approximately one in four new cases of prostate cancer. The estimated disease-specific mortality rate resulting from monotherapy with either surgery or radiotherapy is a disappointing 75%. A multimodality treatment approach could offer more promising results. In addition, several key factors related to surgical treatment of locally advanced prostate cancer may optimize the oncologic results and minimize patient morbidity. In this report, we summarize some of the anatomic features and technical concepts associated with the surgical management of this disease and review recently published results of the outcomes of surgery and neoadjuvant or adjuvant chemohormonal therapy for locally advanced prostate cancer.
约四分之一的前列腺癌新发病例被诊断为局部进展性前列腺癌。仅采用手术或放疗单一疗法导致的疾病特异性死亡率估计高达75%，令人失望。多模式治疗方法可能会带来更有希望的结果。此外，一些与局部进展性前列腺癌手术治疗相关的关键因素可能会优化肿瘤学治疗效果，并将患者的发病率降至最低。在本报告中，我们总结了与该疾病手术管理相关的一些解剖学特征和技术概念，并回顾了最近发表的关于局部进展性前列腺癌手术及新辅助或辅助化学激素治疗结果的研究。
