Vliegenthart Johannes F G
Bijvoet Center, Division Bioorganic Chemistry, Utrecht University, Padualaan 8, NL-3584 CH Utrecht, The Netherlands.
FEBS Lett. 2006 May 22;580(12):2945-50. doi: 10.1016/j.febslet.2006.03.053. Epub 2006 Mar 29.
In the past decades, a gradual increase in the resistance to antibiotics has been observed, leading to a serious thread for successful treatment of bacterial infections. This feature in addition to difficulties in developing adequate drugs against (tropical) diseases caused by parasites has stimulated the interest in vaccines to prevent infections. In principle, various types of cell surface epitopes, characteristic for the invading organism or related to aberrant growth of cells, can be applied to develop vaccines. The progress in establishing the structure of carbohydrate immuno-determinants in conjunction with improvements in carbohydrate synthesis has rendered it feasible to develop new generations of carbohydrate-based vaccines.
在过去几十年中，人们观察到抗生素耐药性逐渐增加，这给细菌感染的成功治疗带来了严重威胁。除了在开发针对寄生虫引起的（热带）疾病的适当药物方面存在困难外，这一特征激发了人们对预防感染疫苗的兴趣。原则上，各种类型的细胞表面表位，无论是入侵生物体所特有的还是与细胞异常生长相关的，都可用于开发疫苗。碳水化合物免疫决定簇结构的确立进展，以及碳水化合物合成的改进，使得开发新一代基于碳水化合物的疫苗成为可能。
