当运动蛋白出现故障时：一种驱动蛋白调节神经元存活。

When a motor goes bad: a kinesin regulates neuronal survival.

作者信息

Kaplan David R, Miller Freda D

机构信息

Cancer Research and Developmental Biology, Hospital for Sick Children Research Institute, Department of Molecular, University of Toronto, Ontario, Canada M5G 1X8.

出版信息

Cell. 2006 Apr 21;125(2):224-6. doi: 10.1016/j.cell.2006.03.031.

DOI:10.1016/j.cell.2006.03.031

PMID:16630809

Abstract

In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4, a microtubule-based molecular motor, regulates the survival of electrically active neurons in the developing brain by modulating the function of poly(ADP-ribose) polymerase-1 in an unexpected way.

摘要

在本期《细胞》杂志中，Midoriikawa等人（2006年）证明，驱动蛋白超家族成员KIF4（一种基于微管的分子马达）通过以一种意想不到的方式调节聚（ADP-核糖）聚合酶-1的功能，来调控发育中大脑里电活性神经元的存活。