内嗅皮质中的诱导性和细胞类型受限操纵。

Inducible and cell-type restricted manipulation in the entorhinal cortex.

作者信息

Nakazawa Kazu

机构信息

Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, Maryland 20892, USA.

出版信息

Neuron. 2006 Apr 20;50(2):183-5. doi: 10.1016/j.neuron.2006.04.007.

DOI:10.1016/j.neuron.2006.04.007

PMID:16630829

Abstract

The entorhinal cortex functions as the gateway to the hippocampal formation. However, its role in formation and consolidation of hippocampus-dependent memory remains relatively unexplored. In this issue of Neuron, Yasuda and Mayford report an elegant cell-type restricted inducible transgenic mouse overexpressing a mutant form of CaM kinase II selectively in superficial layers of medial entorhinal cortex and its upstream regions. These animals display a selective spatial memory deficit during the immediate posttraining period as well as during acquisition in the Morris water maze. Similar to the hippocampus, this time-limited involvement of entorhinal cortex in spatial memory processing suggests a crucial role for hippocampal-entorhinal circuitry in spatial memory formation.

摘要

内嗅皮层作为通往海马结构的门户发挥作用。然而，其在海马依赖性记忆的形成和巩固中的作用仍相对未被探索。在本期《神经元》杂志中，安田和梅福德报道了一种精巧的细胞类型限制性诱导转基因小鼠，该小鼠在内侧内嗅皮层及其上游区域的表层选择性地过表达一种突变形式的钙调蛋白激酶II。这些动物在训练后即刻以及在莫里斯水迷宫实验的习得过程中均表现出选择性空间记忆缺陷。与海马体类似，内嗅皮层在空间记忆处理中的这种限时参与表明海马 - 内嗅神经回路在空间记忆形成中起着关键作用。